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Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion
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November 08, 2017
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1Department of Medical Physiology,Hamamatsu University School of Medicine, 2Division of Vascular Surgery, Second Department of Surgery,Hamamatsu University School of Medicine, 3Department of Applied Biological Chemistry, Graduate School of Agriculture,Kindai University, 4Department of Organ & Tissue Anatomy,Hamamatsu University School of Medicine
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Polyurethane catheter insertion into the aortic lumen and suture ligation of the aorta induce chronic hypoxia due to hypoperfusion of the adventitial vasa vasorum. This article describes a novel animal model of abdominal aortic aneurysm (AAA) with characteristics similar to those of AAA in humans.
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Tanaka, H., Unno, N., Yata, T., Kugo, H., Zaima, N., Sasaki, T., Urano, T. Creation of a Rodent Model of Abdominal Aortic Aneurysm by Blocking Adventitial Vasa Vasorum Perfusion. J. Vis. Exp. (129), e55763, doi:10.3791/55763 (2017).
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