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後根神経節インジェクションおよび後根感覚軸索再生のためのモデルとして傷害をつぶします
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Journal JoVE Neurosciences
Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration
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後根神経節インジェクションおよび後根感覚軸索再生のためのモデルとして傷害をつぶします

16,777 Views

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09:48 min

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May 03, 2017

DOI:

10.3791/55535-v

DOI:
10.3791/55535-v

•

09:48 min
May 03, 2017

•

80 Views
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1John van Geest Center for Brain Repair,University of Cambridge, 2School of Medicine,University of St. Andrews, 3Department of Biological Sciences,University of Southampton

Summary

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This protocol presents the use of a dorsal root ganglion (DRG) injection with a viral vector and a concurrent dorsal root crush injury in an adult rat as a model to study sensory axon regeneration. This model is suitable for investigating the use of gene therapy to promote sensory axon regeneration.

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Cheah, M., Fawcett, J. W., Andrews, M. R. Dorsal Root Ganglion Injection and Dorsal Root Crush Injury as a Model for Sensory Axon Regeneration. J. Vis. Exp. (123), e55535, doi:10.3791/55535 (2017).

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