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Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction
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Médecine
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Journal JoVE Médecine
Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

Murine Left Anterior Descending (LAD) Coronary Artery Ligation: An Improved and Simplified Model for Myocardial Infarction

DOI:
10.3791/55353-v

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10:39 min

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April 02, 2017

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, , , , ,
1Cardiothoracic Surgery Division,Rhode Island Hospital, Brown University Warren Alpert Medical School

Chapitres

  • 00:05Titre
  • 01:07Anesthesia and Intubation
  • 02:50Preparing the Mouse
  • 04:03Left Anterior Descending (LAD) Coronary Ligation
  • 08:43Results: Staining 28 Days Post-op
  • 09:25Conclusion

Summary

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We provide a reliable method for left anterior descending artery (LAD) ligation in a mouse model. This method is comparatively less invasive than other methods, involving endotracheal intubation, a left-sided thoracotomy approach, and thoracentesis. This method can be used as a model for both acute and chronic myocardial infarction (MI).

Tags

Keywords: MurineLeft Anterior Descending (LAD) Coronary Artery LigationMyocardial InfarctionMouse ModelCardiovascular ResearchEndotracheal IntubationSedationOropharynxTracheal IntubationVentilatorThoracotomyCoronary Artery Ligation

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