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小鼠加速动脉硬化的诱导："电线损伤"模型

Journal JoVE
Médecine

This content is Free Access.

Journal JoVE Médecine

Induction of Accelerated Atherosclerosis in Mice: The “Wire-Injury” Model

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小鼠加速动脉硬化的诱导："电线损伤"模型

9,949 Views

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00:05 min

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August 25, 2020

DOI:

10.3791/54571-v

DOI:

10.3791/54571-v

•

00:05 min

August 25, 2020

•

9 Views

Adelina Curaj¹, Wu Zhoujun¹, Mareike Staudt¹, Elisa A. Liehn^1,2

¹Institute for Molecular Cardiovascular Research,RWTH Aachen University, ²Human Genetic Laboratory,University of Medicine and Pharmacy

Summary

本研究描述了小鼠加速动脉硬化诱导的侵入性程序。与其他使用电或低温诱发损伤的方法相比，机械诱导损伤模仿再血管化治疗后人类的再病状况，是研究有关分子机制的理想之选。

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