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Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice
Journal JoVE
Médecine
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Journal JoVE Médecine
Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

Subcutaneous Angiotensin II Infusion using Osmotic Pumps Induces Aortic Aneurysms in Mice

DOI:
10.3791/53191-v

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07:21 min

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September 28, 2015

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, , , , , ,
1Saha Cardiovascular Research Center,University of Kentucky, 2Department of Pharmacology and Nutritional Sciences,University of Kentucky

Chapitres

  • 00:05Titre
  • 00:59Osmotic Pump Filling
  • 03:45Pump Implantation
  • 05:45Results: Aortic Images from Mice Infused with AngII
  • 07:01Conclusion

Summary

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Subcutaneous implantation of osmotic pumps provides a convenient approach for prolonged and consistent delivery of compounds. This approach has been used extensively to study both abdominal and thoracic aortic aneurysms in mice.

Tags

Subcutaneous InfusionAngiotensin IIOsmotic PumpsAortic AneurysmsMiceHypercholesterolemiaGender DependenceAbdominal Aortic AneurysmsThoracic Aortic Aneurysms

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