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Sciences du comportement
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動機付け行動の分子基質を研究するために齧歯類の脳マイクロインジェクション
Journal JoVE
Sciences du comportement
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Journal JoVE Sciences du comportement
Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
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動機付け行動の分子基質を研究するために齧歯類の脳マイクロインジェクション

13,989 Views

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10:05 min

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September 16, 2015

DOI:

10.3791/53018-v

DOI:
10.3791/53018-v

•

10:05 min
September 16, 2015

•

1 Views
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1Virginia Institute for Psychiatric and Behavioral Genetics, Department of Psychiatry,Virginia Commonwealth University School of Medicine, 2Institute for Drug and Alcohol Studies, Departments of Psychiatry, Pharmacology, and Neuroscience,Virginia Commonwealth University School of Medicine

Summary

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Rodents are an appropriate model to investigate the molecular substrates of behavior and complex psychiatric disorders. Brain microinjection in awake rodents can be used to elucidate disease substrates. An efficient and customizable brain microinjection method as well as the execution of an operant paradigm that quantifies motivation is presented.

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Poland, R. S., Bull, C., Syed, W. A., Bowers, M. S. Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior. J. Vis. Exp. (103), e53018, doi:10.3791/53018 (2015).

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