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在组织变性/再生和癌症的研究利用小鼠诱导端粒酶等位基因
Journal JoVE
Médecine
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Journal JoVE Médecine
Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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在组织变性/再生和癌症的研究利用小鼠诱导端粒酶等位基因

9,510 Views

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08:34 min

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April 13, 2015

DOI:

10.3791/52599-v

DOI:
10.3791/52599-v

•

08:34 min
April 13, 2015

•

3 Views
, , , , , ,
1Department of Cancer Biology,UT MD Anderson Cancer Center, 2Novartis Institutes for Biomedical Research, 3Sanofi US, 4Institute of Applied Cancer Science,UT MD Anderson Cancer Center

Summary

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Telomere and telomerase play essential roles in ageing and tumorigenesis. The goal of this protocol is to show how to generate two murine inducible telomerase knock-in alleles and how to utilize them in the studies of tissue degeneration/regeneration and cancer.

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Cite this Article

Shingu, T., Jaskelioff, M., Yuan, L., Ding, Z., Protopopov, A., Kost-Alimova, M., Hu, J. Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer. J. Vis. Exp. (98), e52599, doi:10.3791/52599 (2015).

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