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Ein<em> In-vitro-</em> Modell für die Untersuchung der zellulären Pathophysiologie in Globoidzell- Leukodystrophie
Journal JoVE
Neurosciences
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Journal JoVE Neurosciences
An In Vitro Model for the Study of Cellular Pathophysiology in Globoid Cell Leukodystrophy
DOI:

07:45 min

October 21, 2014

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Chapitres

  • 00:05Titre
  • 01:16Coverslip Preparation
  • 02:37Globoid Cell Induction in Mixed Glial Cultures
  • 04:30Analysis and Characterization of Globoid Cells in Primary Culture
  • 06:12Results: Representative Microglial Cells After Psychosine and Latex Bead Phagocytosis
  • 07:15Conclusion

Summary

Traduction automatique

Globoid cells are a defining pathological feature of Krabbe disease, a leukodystrophy currently lacking an effective long-term therapy. We have developed a cell culture model to study the innate biology and pathogenic potential of activated microglia and their transformation into globoid cells.

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