Mouse Models for Graft Arteriosclerosis

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Medicine

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Medicine

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JoVE Journal Medicine

Mouse Models for Graft Arteriosclerosis

DOI:

10.3791/50290-v

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07:37 min

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May 14, 2013

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Lingfeng Qin, Luyang Yu, Wang Min

¹Department of Surgery,Yale University School of Medicine , ²Department of Pathology,Yale University School of Medicine

Chapters

00:05Title
01:09Donor Procedure
02:15Recipient Procedure
06:33Results: Graft Analysis
07:24Conclusion

Summary

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We describe protocols for our mouse graft arteriosclerois (GA) models which involve interposition of a mouse vessel segment into a recipient of the same inbred strain. By backcrossing additional genetic changes into the vessel donor, the model can assess the effect of specific genes on GA.

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