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Immunology and Infection

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Brug af BLT Humaniseret Mouse som en stamcelle baseret genterapi tumormodel
 
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Brug af BLT Humaniseret Mouse som en stamcelle baseret genterapi tumormodel

Article DOI: 10.3791/4181-v 06:59 min December 18th, 2012
December 18th, 2012

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résumé

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Generering og karakterisering af tumorspecifikke T-celler under anvendelse af humaniserede mus er beskrevet her. Humant thymisk væv og genetisk modificerede humane hæmatopoietiske stamceller transplanteres ind immunkompromitterede mus. Dette resulterer i rekonstituering af et manipuleret humant immunsystem muliggør in vivo undersøgelse af anti-tumor immunrespons.

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Cancer Biology Stem Cell Biology Immunology Biomedical Engineering Medicine Bioengineering Genetics onkologi Humaniserede mus stamcelletransplantation stamceller, T-celler cancer dyremodel
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