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Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy
 

Micro-Mechanical Characterization of Lung Tissue Using Atomic Force Microscopy

Article DOI: 10.3791/2911-v • 11:11 min • August 28th, 2011
August 28th, 2011 •
1, 1
1Molecular and Integrative Physiological Sciences, Department of Environmental Health, Harvard School of Public Health

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The stiffness of the extracellular matrix strongly influences multiple behaviors of adherent cells. Matrix stiffness varies spatially throughout a tissue, and undergoes modification in various disease conditions. Here we develop methods to characterize spatial variations in stiffness in normal and fibrotic mouse lung tissue using atomic force microscopy microindentation.

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Micro-Mechanical Characterization Lung Tissue Atomic Force Microscopy Matrix Stiffness Adherent Cells Tissue Stiffness Macro Scale Spatial Variation Disease Processes Tissue Remodeling Matrix Remodeling Cellular Physiology Health And Disease Lung Parenchyma Murine Lung Tissue AFM Microindentation Local Tissue Shear Modulus
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