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Generation of Multivirus-specific T Cells to Prevent/treat Viral Infections after Allogeneic Hematopoietic Stem Cell Transplant
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Chapitres
- 00:05Titre
- 01:49DC Nucleofection
- 04:01T Cell Stimulation
- 06:18G-Rex Expansion of Multivirus-specific T Cells Generates High Numbers of Polyfunctional, Antigen-specific Effector T Cells
- 08:14Conclusion
A rapid, simple and cost-effective protocol for the generation of donor-derived multivirus-specific CTLs (rCTL) for infusion to allogeneic hematopoietic stem cell transplant (HSCT) recipients at risk of developing CMV, Adv or EBV infections. This manufacturing process is GMP-compliant and should ensure the broader implementation of T-cell immunotherapy beyond specialized centers.
