Multisystem Monitoring in Rabbit Model: A Method to Assess Neuro-Cardiac and Respiratory Parameters to Study the Oral Drug-induced Triggers for Arrhythmia and Seizures

Before administering the medication, collect 10 to 20 minutes of baseline EEG-ECG-video from the untreated rabbit as demonstrated. For the oral administration of a medication of interest, mix 0.3 milligrams per kilogram of the drug of interest in three milliliters of food-grade applesauce and load the mixture into a three-milliliter oral syringe.

Gently lifting the upper lip of the rabbit, slide the tip of the syringe into the side of the mouth that is unobstructed by the rabbit's teeth, and inject the entire volume of drug-supplemented applesauce into the rabbit's mouth. Then, collect two hours of EEG-ECG-video data before returning the rabbit to its home cage for routine care.