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全身和局部给药治疗的中枢神经系统疾病的啮齿动物模型

Journal JoVE
Neurosciences

This content is Free Access.

Journal JoVE Neurosciences

Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models

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全身和局部给药治疗的中枢神经系统疾病的啮齿动物模型

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11:51 min

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August 16, 2010

DOI:

DOI:

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11:51 min

August 16, 2010

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12 Views

Laura Serwer¹, Rintaro Hashizume¹, Tomoko Ozawa¹, C. David James¹

¹Department of Neurological Surgery,University of California, San Francisco – UCSF

Summary

彻底在中枢神经系统的药物，临床前试验，往往涉及的评估和比较药物体内分布与管理的具体路线协会。在这里，三个系统性交付的常用方法（静脉，腹腔，口腔），以及为本地传递方法（对流增强交付）在小鼠体内证明。

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