A Mouse Model to Study Brain Physiology During Cardiac Arrest

A Mouse Model to Study Brain Physiology During Cardiac Arrest

April 14, 2023

Author Spotlight: A Unique Mouse Model of Asphyxia-Induced Cardiac Arrest

Cardiac Arrest and Resuscitation Procedure in a Murine Model

Ran Li¹, Weina Duan¹, Dong Zhang², Ulrike Hoffmann³, Junjie Yao², Wei Yang¹, Huaxin Sheng¹

¹Multidisciplinary Brain Protection Program, Department of Anesthesiology,Duke University Medical Center, ²Department of Biomedical Engineering,Duke University, ³Department of Anesthesiology and Pain Management,UT Southwestern University Medical Center

Summary

This protocol demonstrates a unique mouse model of asphyxia cardiac arrest that does not require chest compression for resuscitation. This model is useful for monitoring and imaging the dynamics of brain physiology during cardiac arrest and resuscitation.

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