Ralph N. Martins Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences Edith Cowan University Biography Publications Institution JoVE Articles Ralph N. Martins has not added a biography. If you are Ralph N. Martins and would like to personalize this page please email our Author Liaison for assistance. Publications Developing an International Network for Alzheimer Research: The Dominantly Inherited Alzheimer Network Clinical Investigation. Oct, 2012 | Pubmed ID: 23139856 Stronger Effect of Amyloid Load Than APOE Genotype on Cognitive Decline in Healthy Older Adults Neurology. Oct, 2012 | Pubmed ID: 23071163 Protocol for a Randomized Controlled Trial Evaluating the Effect of Physical Activity on Delaying the Progression of White Matter Changes on MRI in Older Adults with Memory Complaints and Mild Cognitive Impairment: The AIBL Active Trial BMC Psychiatry. Oct, 2012 | Pubmed ID: 23050829 Rapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β Journal of Alzheimer's Disease : JAD. Sep, 2012 | Pubmed ID: 23001710 Pharmacological Effects of Cannabinoids on the Reference and Working Memory Functions in Mice Psychopharmacology. Aug, 2012 | Pubmed ID: 22903389 Latrepirdine (Dimebonâ„¢) Enhances Autophagy and Reduces Intracellular GFP-Aβ42 Levels in Yeast Journal of Alzheimer's Disease : JAD. Jan, 2012 | Pubmed ID: 22903131 Blood-Based Protein Biomarkers for Diagnosis of Alzheimer Disease Archives of Neurology. Jul, 2012 | Pubmed ID: 22801742 Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease The New England Journal of Medicine. Aug, 2012 | Pubmed ID: 22784036 Regional Dynamics of Amyloid-β Deposition in Healthy Elderly, Mild Cognitive Impairment and Alzheimer's Disease: a Voxelwise PiB-PET Longitudinal Study Brain : a Journal of Neurology. Jul, 2012 | Pubmed ID: 22628162 Robust Homeostasis of Presenilin1 Protein Levels by Transcript Regulation Neuroscience Letters. Jun, 2012 | Pubmed ID: 22580062 Multiple γ-secretase Product Peptides Are Coordinately Increased in Concentration in the Cerebrospinal Fluid of a Subpopulation of Sporadic Alzheimer's Disease Subjects Molecular Neurodegeneration. 2012 | Pubmed ID: 22534039 Altered Expression of Alzheimer's Disease-related Proteins in Male Hypogonadal Mice Endocrinology. Jun, 2012 | Pubmed ID: 22514046 Use of the CogState Brief Battery in the Assessment of Alzheimer's Disease Related Cognitive Impairment in the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study Journal of Clinical and Experimental Neuropsychology. 2012 | Pubmed ID: 22248010 Cortical Surface Mapping Using Topology Correction, Partial Flattening and 3D Shape Context-based Non-rigid Registration for Use in Quantifying Atrophy in Alzheimer's Disease Journal of Neuroscience Methods. Mar, 2012 | Pubmed ID: 22226742 Evaluation of Color Preference in Zebrafish for Learning and Memory Journal of Alzheimer's Disease : JAD. 2012 | Pubmed ID: 22008261 Predictors of Rapid Cognitive Decline in Alzheimer's Disease: Results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Ageing International Psychogeriatrics / IPA. Feb, 2012 | Pubmed ID: 21749739 Functional Effects of Genetic Polymorphism in Inflammatory Genes in Subjective Memory Complainers Neurobiology of Aging. Jun, 2012 | Pubmed ID: 20961668 Direct Exposure of Guinea Pig CNS to Human Luteinizing Hormone Increases Cerebrospinal Fluid and Cerebral Beta Amyloid Levels Neuroendocrinology. 2011 | Pubmed ID: 21985789 Homocysteine, Vitamin B12, and Folic Acid Levels in Alzheimer's Disease, Mild Cognitive Impairment, and Healthy Elderly: Baseline Characteristics in Subjects of the Australian Imaging Biomarker Lifestyle Study Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21891867 The Dynamics of CD147 in Alzheimer's Disease Development and Pathology Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21694447 Alternative Processing of γ-secretase Substrates in Common Forms of Mild Cognitive Impairment and Alzheimer's Disease: Evidence for γ-secretase Dysfunction Annals of Neurology. Jun, 2011 | Pubmed ID: 21681798 Cognition and Beta-amyloid in Preclinical Alzheimer's Disease: Data from the AIBL Study Neuropsychologia. Jul, 2011 | Pubmed ID: 21529702 Memory Function in a Mouse Genetic Model of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2011 | Pubmed ID: 21460433 New Lexicon and Criteria for the Diagnosis of Alzheimer's Disease Lancet Neurology. Apr, 2011 | Pubmed ID: 21435594 Advances in Structural and Molecular Neuroimaging in Alzheimer's Disease The Medical Journal of Australia. Feb, 2011 | Pubmed ID: 21401483 A Web-based Normative Data Tool for Assessing Cognitive Performance in Healthy Older Australians The Medical Journal of Australia. Feb, 2011 | Pubmed ID: 21401481 Effects of Anticholinergic Drugs on Cognitive Function in Older Australians: Results from the AIBL Study Dementia and Geriatric Cognitive Disorders. 2011 | Pubmed ID: 21389718 Independent Contribution of Temporal Beta-amyloid Deposition to Memory Decline in the Pre-dementia Phase of Alzheimer's Disease Brain : a Journal of Neurology. Mar, 2011 | Pubmed ID: 21310725 Zebrafish As a Tool in Alzheimer's Disease Research Biochimica Et Biophysica Acta. Mar, 2011 | Pubmed ID: 20920580 Ocular Biomarkers for Early Detection of Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20847434 Larger Temporal Volume in Elderly with High Versus Low Beta-amyloid Deposition Brain : a Journal of Neurology. Nov, 2010 | Pubmed ID: 20739349 APOE Genotype Results in Differential Effects on the Peripheral Clearance of Amyloid-beta42 in APOE Knock-in and Knock-out Mice Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20555142 Addressing Population Aging and Alzheimer's Disease Through the Australian Imaging Biomarkers and Lifestyle Study: Collaboration with the Alzheimer's Disease Neuroimaging Initiative Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2010 | Pubmed ID: 20451879 Plasma Amyloid-beta As a Biomarker in Alzheimer's Disease: the AIBL Study of Aging Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20413897 Relationship Between Atrophy and Beta-amyloid Deposition in Alzheimer Disease Annals of Neurology. Mar, 2010 | Pubmed ID: 20373343 Extensive Proteomic Screening Identifies the Obesity-related NYGGF4 Protein As a Novel LRP1-interactor, Showing Reduced Expression in Early Alzheimer's Disease Molecular Neurodegeneration. 2010 | Pubmed ID: 20205790 Profiling Brain and Plasma Lipids in Human APOE Epsilon2, Epsilon3, and Epsilon4 Knock-in Mice Using Electrospray Ionization Mass Spectrometry Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20164599 Predicting Memory Decline As a Risk Factor for Alzheimer's Disease in Older Post-menopausal Women: Quod Erat Demonstrandum? International Psychogeriatrics / IPA. Mar, 2010 | Pubmed ID: 19814842 Beta Amyloid and Hyperphosphorylated Tau Deposits in the Pancreas in Type 2 Diabetes Neurobiology of Aging. Sep, 2010 | Pubmed ID: 18950899 Cholesterol Metabolism and Transport in the Pathogenesis of Alzheimer's Disease Journal of Neurochemistry. Dec, 2009 | Pubmed ID: 20050287 The Structure and Function of Alzheimer's Gamma Secretase Enzyme Complex Critical Reviews in Clinical Laboratory Sciences. 2009 | Pubmed ID: 19958215 Alcadein Cleavages by Amyloid Beta-precursor Protein (APP) Alpha- and Gamma-secretases Generate Small Peptides, P3-Alcs, Indicating Alzheimer Disease-related Gamma-secretase Dysfunction The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19864413 Dietary Composition Modulates Brain Mass and Solubilizable Abeta Levels in a Mouse Model of Aggressive Alzheimer's Amyloid Pathology Molecular Neurodegeneration. 2009 | Pubmed ID: 19845940 Complex Splicing and Neural Expression of Duplicated Tau Genes in Zebrafish Embryos Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19584432 Independent and Cooperative Action of Psen2 with Psen1 in Zebrafish Embryos Experimental Cell Research. Oct, 2009 | Pubmed ID: 19563801 Olfactory Dysfunction is Associated with Subjective Memory Complaints in Community-dwelling Elderly Individuals Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19494438 The Relationship Between Memory Complaints, Perceived Quality of Life and Mental Health in Apolipoprotein Eepsilon4 Carriers and Non-carriers Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19494432 The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study of Aging: Methodology and Baseline Characteristics of 1112 Individuals Recruited for a Longitudinal Study of Alzheimer's Disease International Psychogeriatrics / IPA. Aug, 2009 | Pubmed ID: 19470201 Abeta Aggregation and Possible Implications in Alzheimer's Disease Pathogenesis Journal of Cellular and Molecular Medicine. Mar, 2009 | Pubmed ID: 19374683 Androgens and Alzheimer's Disease Current Opinion in Endocrinology, Diabetes, and Obesity. Jun, 2009 | Pubmed ID: 19373081 Association of Cardiovascular Factors and Alzheimer's Disease Plasma Amyloid-beta Protein in Subjective Memory Complainers Journal of Alzheimer's Disease : JAD. 2009 | Pubmed ID: 19363264 Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the Tx Mouse is a Better Model of Hepatic Than Brain Cu Toxicity International Journal of Clinical and Experimental Medicine. 2008 | Pubmed ID: 19079689 Distinct Effects of Testosterone on Plasma and Cerebrospinal Fluid Amyloid-beta Levels Journal of Alzheimer's Disease : JAD. Sep, 2008 | Pubmed ID: 18780973 Association of Alleles Carried at TNFA -850 and BAT1 -22 with Alzheimer's Disease Journal of Neuroinflammation. 2008 | Pubmed ID: 18715507 Luteinizing Hormone Levels Are Positively Correlated with Plasma Amyloid-beta Protein Levels in Elderly Men Journal of Alzheimer's Disease : JAD. Jun, 2008 | Pubmed ID: 18560131 Infection and Alzheimer's Disease: the APOE Epsilon4 Connection and Lipid Metabolism Journal of Alzheimer's Disease : JAD. May, 2008 | Pubmed ID: 18487850 Gonadotropins and Cognition in Older Women Journal of Alzheimer's Disease : JAD. Apr, 2008 | Pubmed ID: 18430994 Fluoro-2-deoxy-D-glucose (FDG)-PET in APOEepsilon4 Carriers in the Australian Population Journal of Alzheimer's Disease : JAD. Mar, 2008 | Pubmed ID: 18376055 B-vitamins Reduce Plasma Levels of Beta Amyloid Neurobiology of Aging. Feb, 2008 | Pubmed ID: 17113685 Androgens in the Etiology of Alzheimer's Disease in Aging Men and Possible Therapeutic Interventions Journal of Alzheimer's Disease : JAD. Sep, 2007 | Pubmed ID: 17917157 Cerebrospinal Fluid Antimicroglial Antibodies in Alzheimer Disease: a Putative Marker of an Ongoing Inflammatory Process Experimental Gerontology. Apr, 2007 | Pubmed ID: 17140756 The Role of Presenilin and Its Interacting Proteins in the Biogenesis of Alzheimer's Beta Amyloid Neurochemical Research. Apr-May, 2007 | Pubmed ID: 16944319 Oxidative Stress in a Rat Model of Chronic Gliosis Neurobiology of Aging. Jul, 2007 | Pubmed ID: 16797785 Redox Proteomics Identification of Oxidatively Modified Brain Proteins in Inherited Alzheimer's Disease: an Initial Assessment Journal of Alzheimer's Disease : JAD. Dec, 2006 | Pubmed ID: 17183150 Mutations in Progranulin Explain Atypical Phenotypes with Variants in MAPT Brain : a Journal of Neurology. Nov, 2006 | Pubmed ID: 17071927 Reproductive Hormones Modulate Oxidative Stress in Alzheimer's Disease Antioxidants & Redox Signaling. Nov-Dec, 2006 | Pubmed ID: 17034349 A Functional Polymorphism Within Plasminogen Activator Urokinase (PLAU) is Associated with Alzheimer's Disease Human Molecular Genetics. Aug, 2006 | Pubmed ID: 16825285 The Role of Gonadotropins in Alzheimer's Disease: Potential Neurodegenerative Mechanisms Endocrine. Apr, 2006 | Pubmed ID: 16785601 Interaction Between Testosterone and Apolipoprotein E Epsilon4 Status on Cognition in Healthy Older Men The Journal of Clinical Endocrinology and Metabolism. Mar, 2006 | Pubmed ID: 16368754 Plasma Abeta42 Correlates Positively with Increased Body Fat in Healthy Individuals Journal of Alzheimer's Disease : JAD. Dec, 2005 | Pubmed ID: 16340084 Common Versus Uncommon Causes of Dementia International Psychogeriatrics / IPA. 2005 | Pubmed ID: 16240481 TNF Polymorphisms in Alzheimer Disease and Functional Implications on CSF Beta-amyloid Levels Human Mutation. Jul, 2005 | Pubmed ID: 15895461 Dementia and Testosterone Levels in Men JAMA : the Journal of the American Medical Association. Feb, 2005 | Pubmed ID: 15687304 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research. Feb, 2005 | Pubmed ID: 15668631 Alzheimer Amyloid Precursor Aspartyl Proteinase Activity in CHAPSO Homogenates of Spodoptera Frugiperda Cells Alzheimer Disease and Associated Disorders. Oct-Dec, 2004 | Pubmed ID: 15592142 Frequency of Tau Mutations in Familial and Sporadic Frontotemporal Dementia and Other Tauopathies Journal of Neurology. Sep, 2004 | Pubmed ID: 15372253 The Role of Beta Amyloid in Alzheimer's Disease: Still a Cause of Everything or the Only One Who Got Caught? Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Oct, 2004 | Pubmed ID: 15304237 Aging, Gender and APOE Isotype Modulate Metabolism of Alzheimer's Abeta Peptides and F-isoprostanes in the Absence of Detectable Amyloid Deposits Journal of Neurochemistry. Aug, 2004 | Pubmed ID: 15287908 Effects of Apolipoprotein E on the Human Immunodeficiency Virus Protein Tat in Neuronal Cultures and Synaptosomes Journal of Neuroscience Research. Aug, 2004 | Pubmed ID: 15264223 One Year Follow-up Study of the Association Between Chemical Castration, Sex Hormones, Beta-amyloid, Memory and Depression in Men Psychoneuroendocrinology. Sep, 2004 | Pubmed ID: 15219659 Luteinizing Hormone, a Reproductive Regulator That Modulates the Processing of Amyloid-beta Precursor Protein and Amyloid-beta Deposition The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 14871891 Amyloid-beta-induced Toxicity of Primary Neurons is Dependent Upon Differentiation-associated Increases in Tau and Cyclin-dependent Kinase 5 Expression Journal of Neurochemistry. Feb, 2004 | Pubmed ID: 14720205 Molecular and Cellular Basis for Anti-amyloid Therapy in Alzheimer Disease Alzheimer Disease and Associated Disorders. Oct-Dec, 2003 | Pubmed ID: 14657791 Amyloid-beta: a Chameleon Walking in Two Worlds: a Review of the Trophic and Toxic Properties of Amyloid-beta Brain Research. Brain Research Reviews. Sep, 2003 | Pubmed ID: 14499458 Increased Levels of Apolipoprotein E in the Frontal Cortex of Subjects with Schizophrenia Biological Psychiatry. Sep, 2003 | Pubmed ID: 13129656 Two Novel Presenilin-1 Mutations (Y256S and Q222H) Are Associated with Early-onset Alzheimer's Disease Neurobiology of Aging. Sep, 2003 | Pubmed ID: 12885573 Apolipoprotein D Levels Are Elevated in Prefrontal Cortex of Subjects with Alzheimer's Disease: No Relation to Apolipoprotein E Expression or Genotype Biological Psychiatry. Jul, 2003 | Pubmed ID: 12873803 XB51 Isoforms Mediate Alzheimer's Beta-amyloid Peptide Production by X11L (X11-like Protein)-dependent and -independent Mechanisms The Biochemical Journal. Aug, 2003 | Pubmed ID: 12780348 Can Testosterone Replacement Decrease the Memory Problem of Old Age? Medical Hypotheses. Jun, 2003 | Pubmed ID: 12699720 Reduction of Inclusion Body Pathology in ApoE-deficient Mice Fed a Combination of Antioxidants Free Radical Biology & Medicine. Apr, 2003 | Pubmed ID: 12684092 Mutations in the Tau Gene That Cause an Increase in Three Repeat Tau and Frontotemporal Dementia Brain : a Journal of Neurology. Apr, 2003 | Pubmed ID: 12615641 Expanding the Association Between the APOE Gene and the Risk of Alzheimer's Disease: Possible Roles for APOE Promoter Polymorphisms and Alterations in APOE Transcription Journal of Neurochemistry. Mar, 2003 | Pubmed ID: 12614323 Elevated Luteinizing Hormone Expression Colocalizes with Neurons Vulnerable to Alzheimer's Disease Pathology Journal of Neuroscience Research. Nov, 2002 | Pubmed ID: 12391612 Senile Plaque Composition and Posttranslational Modification of Amyloid-beta Peptide and Associated Proteins Peptides. Jul, 2002 | Pubmed ID: 12128091 Association of Interleukin-1 Polymorphisms with Alzheimer's Disease in Australia Annals of Neurology. Jun, 2002 | Pubmed ID: 12112093 Altered Glycosylation of Acetylcholinesterase in APP (SW) Tg2576 Transgenic Mice Occurs Prior to Amyloid Plaque Deposition Journal of Neurochemistry. May, 2002 | Pubmed ID: 12065653 Intraneuronal Advanced Glycation Endproducts in Presenilin-1 Alzheimer's Disease Neuroreport. Apr, 2002 | Pubmed ID: 11973454 Transition Metal Chelator Therapy--a Potential Treatment for Alzheimer's Disease? Frontiers in Bioscience : a Journal and Virtual Library. Apr, 2002 | Pubmed ID: 11897554 Association Between the Presenilin-1 Mutation Glu318Gly and Complaints of Memory Impairment Neurobiology of Aging. Jan-Feb, 2002 | Pubmed ID: 11755019 Amyloid Beta Protein Precursor Metabolism As a Modulator of Islet Beta-cell Function Journal of Alzheimer's Disease : JAD. Aug, 2001 | Pubmed ID: 12214043 Cuidados e manutenção regular de um peixe-zebra ( Avdesh Avdesh*1,2, Mengqi Chen*1,3, Mathew T. Martin-Iverson1,2,4, Alinda Mondal1,3, Daniel Ong1, Stephanie Rainey-Smith1,3, Kevin Taddei1,3, Michael Lardelli5, David M. Groth6, Giuseppe Verdile1,3, Ralph N. Martins1,2,3,7 1Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences, Edith Cowan University, 2Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, University of Western Australia, 3McCusker Alzheimer's Research foundation, 4School of Medicine and Pharmacology, University of Western Australia, 5Department of Molecular and Biomedical Sciences, University of Adelaide, 6School of Biomedical Sciences, Curtin University of Technology, 7School of Psychiatry and Clinical Neurosciences, University of Western Australia JoVE 4196 Biologie
Cuidados e manutenção regular de um peixe-zebra ( Avdesh Avdesh*1,2, Mengqi Chen*1,3, Mathew T. Martin-Iverson1,2,4, Alinda Mondal1,3, Daniel Ong1, Stephanie Rainey-Smith1,3, Kevin Taddei1,3, Michael Lardelli5, David M. Groth6, Giuseppe Verdile1,3, Ralph N. Martins1,2,3,7 1Centre of Excellence for Alzheimer's Disease Research and Care, School of Medical sciences, Edith Cowan University, 2Centre for Clinical Research in Neuropsychiatry, Graylands Hospital, University of Western Australia, 3McCusker Alzheimer's Research foundation, 4School of Medicine and Pharmacology, University of Western Australia, 5Department of Molecular and Biomedical Sciences, University of Adelaide, 6School of Biomedical Sciences, Curtin University of Technology, 7School of Psychiatry and Clinical Neurosciences, University of Western Australia JoVE 4196 Biologie