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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
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06:39 min
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June 13, 2021
DOI:
1Molecular Developmental Biology Program,Cincinnati Children’s Hospital Medical Center, 2Division of Human Genetics,Cincinnati Children’s Hospital Medical Center, 3Department of Pediatrics,University of Cincinnati College of Medicine, 4Division of Veterinary Services,Cincinnati Children’s Hospital Medical Center
Summary
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The chronic psychosocial stress (CGS) paradigm employs clinically relevant stressors during pregnancy in mice to model psychiatric disorders of mothers and infants. Here, we provide a step-by-step procedure of applying the CGS paradigm and downstream assessments to validate this model.
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Zoubovsky, S. P., Wilder, A., Muglia, L. Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants. J. Vis. Exp. (172), e62464, doi:10.3791/62464 (2021).
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