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Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes
JoVE Revista
Medicina
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JoVE Revista Medicina
Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes

12,076 Views

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05:06 min

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May 05, 2020

DOI:

10.3791/61104-v

DOI:
10.3791/61104-v

•

05:06 min
May 05, 2020

•

42 Views
, , , , , ,
1Department of Cardiovascular Physiology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences,Okayama University, 2Institute of Laboratory Animals, Graduate School of Medicine,Kyoto University

Summary

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We present a model of ischemic heart disease using cardiomyocytes derived from human induced pluripotent stem cells, together with a method for quantitative evaluation of tissue damage caused by ischemia. This model can provide a useful platform for drug screening and further research on ischemic heart disease.

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Cite this Article

Liu, Y., Liang, Y., Wang, M., Wang, C., Wei, H., Naruse, K., Takahashi, K. Model of Ischemic Heart Disease and Video-Based Comparison of Cardiomyocyte Contraction Using hiPSC-Derived Cardiomyocytes. J. Vis. Exp. (159), e61104, doi:10.3791/61104 (2020).

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