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Journal / Cancer Research / Radionuclide-fluorescence Reporter Gene Imaging…
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Cancer Research

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JoVE Journal Cancer Research
Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models
 

Radionuclide-fluorescence Reporter Gene Imaging to Track Tumor Progression in Rodent Tumor Models

Article DOI: 10.3791/57088-v • 10:04 min • March 13th, 2018
March 13th, 2018 •
1, 1, 1, 1, 1, 1, 1
1Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London

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We describe a protocol for preclinical in vivo tracking of cancer metastasis. It is based on a radionuclide-fluorescence reporter combining the sodium iodide symporter, detected by non-invasive [18F]tetrafluoroborate-PET, and a fluorescent protein for streamlined ex vivo confirmation. The method is applicable for preclinical in vivo cell tracking beyond tumor biology.

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Radionuclide-fluorescence Reporter Gene Imaging Tumor Progression Rodent Tumor Models Live Rodents Imaging Positron Emission Tomography Fluorophor Ex Vivo Confirmation Cancer Cell Tracking PET Tracer Automated Synthesis Reduction Of Animal Use Preclinical Testing Therapeutics Tracking
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