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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine
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Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

Enzymatic Cascade Reactions for the Synthesis of Chiral Amino Alcohols from L-lysine

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09:14 min

February 16, 2018

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Capítulos

  • 00:04Título
  • 00:48Semi-preparative One-pot Biocatalytic Reaction, Reaction Monitoring, and Product Analysis
  • 03:17Semi-preparative One-pot Biocatalytic Reaction: Second and Third Steps
  • 06:01Results: Investigation of Pyridoxal Phosphate Dependent Decarboxylase (PLP DC) Activities towards Hydroxy Lysine Derivatives
  • 07:56Conclusion

Summary

Traducción Automática

Chiral amino alcohols are versatile molecules for use as scaffolds in organic synthesis. Starting from L-lysine, we synthesize amino alcohols by an enzymatic cascade reaction combining diastereoselective C-H oxidation catalyzed by dioxygenase followed by cleavage of the carboxylic acid moiety of the corresponding hydroxyl amino acid by a decarboxylase.

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