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Contractility Measurements of Human Uterine Smooth Muscle to Aid Drug Development
1Harris-Wellbeing Preterm Birth Research Centre, Department of Cellular and Molecular Physiology, Institute of Translational Medicine,University of Liverpool, 2School of Biomedical Sciences,The University of Queensland, 3Faculty of Chemistry, Institute of Biological Chemistry,University of Vienna, 4Institute for Molecular Bioscience,University of Queensland, 5Center for Physiology and Pharmacology,Medical University of Vienna
Capítulos
- 00:05Título
- 00:49Tissue Preparation and Strip Dissection
- 03:00Tissue Mounting
- 04:06Myometrial Contraction Analysis
- 05:28Results: Representative Effects and Receptor Selectivity of a Novel Compound in Human Myometrial Contraction
- 06:41Conclusion
This article describes experimental protocols to study ex vivo contractions of human myometrium and their application in drug discovery. This technique is used to improve the understanding of myometrial physiology and pathophysiology as well as to validate pharmacological data from novel research probes or drug leads.
