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High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay
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High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay
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November 05, 2017
DOI:
1Department of Human Genetics, Donders Institute for Brain, Cognition and Behaviour,Radboud University Medical Center, 2Centre for Molecular and Biomolecular Informatics, Radboud Institute for Molecular Life Sciences,Radboud University Medical Center, 3Department of Neurology, Donders Institute for Brain, Cognition and Behaviour,Radboud University Medical Center
Summary
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The island assay is a relatively new, cost-effective assay that can be used to evaluate the basic locomotor behavior of Drosophila melanogaster. This manuscript describes algorithms for automatic data processing and objective quantification of island assay data, making this assay a sensitive, high-throughput readout for large genetic or pharmacological screens.
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Eidhof, I., Fenckova, M., Elurbe, D. M., van de Warrenburg, B., Castells Nobau, A., Schenck, A. High-throughput Analysis of Locomotor Behavior in the Drosophila Island Assay. J. Vis. Exp. (129), e55892, doi:10.3791/55892 (2017).
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