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Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens
JoVE Revista
Inmunología y contagio
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JoVE Revista Inmunología y contagio
Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens

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09:53 min

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February 06, 2017

DOI:

10.3791/54991-v

DOI:
10.3791/54991-v

•

09:53 min
February 06, 2017

•

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1Division of Infection and Immunity and Systems Immunity Research Institute,Cardiff University, 2Department of Oncology,University Hospital of Lausanne (CHUV), 3Ludwig Insitutue for Cancer Research, Lausanne Branch,University of Lausanne

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X-ray CrystallographyBiophysicsFunctional AssaysT-cell ReceptorCancer AntigensT-cell ImmunologyReceptor-ligand InteractionsProtein RefoldingHLABeta 2-MTCR Alpha/beta ChainsAnion Exchange ChromatographyStructural AnalysisBiophysical AnalysisImmune ResponsesTherapyDiagnosis

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MacLachlan, B. J., Greenshields-Watson, A., Mason, G. H., Schauenburg, A. J., Bianchi, V., Rizkallah, P. J., Sewell, A. K., Fuller, A., Cole, D. K. Using X-ray Crystallography, Biophysics, and Functional Assays to Determine the Mechanisms Governing T-cell Receptor Recognition of Cancer Antigens. J. Vis. Exp. (120), e54991, doi:10.3791/54991 (2017).

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