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Bunların Anti layişmanya Faaliyet karışık Lizin tipi / Arjinin-monomerleri ve Değerlendirilmesi peptoidler Sentezi için etkili bir yöntem
JoVE Revista
Bioquímica
This content is Free Access.
JoVE Revista Bioquímica
An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
DOI:

12:02 min

November 02, 2016

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Capítulos

  • 00:05Título
  • 01:09Synthesis of a Linear Peptoid
  • 05:08Side-chain Deprotection and Cleavage from Resin
  • 06:32Cytotoxicity Assay against Leishmania mexicana Axenic Amastigotes
  • 09:12Results: Synthesis and Characterization of Peptoids and Their Cytotoxicity to Leishmania mexicana
  • 10:33Conclusion

Summary

Traducción Automática

A protocol to synthesize peptoids with mixed cationic functionality in the same sequence is presented (lysine- and arginine-type monomers). Subsequent testing of these compounds against Leishmania mexicana, the protozoan parasites that cause cutaneous leishmaniasis, is also described.

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