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Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion
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Neurociencias
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JoVE Revista Neurociencias
Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion

8,876 Views

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09:14 min

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April 05, 2016

DOI:

10.3791/53331-v

DOI:
10.3791/53331-v

•

09:14 min
April 05, 2016

•

5 Views
, , , , ,
1Molecular Neurobiology Laboratory, Department of Neurology,Heinrich-Heine-University Medical Center, 2Institute of Microsystems Technology,Hamburg University of Technology, 3Biomechanical Laboratory,BG Trauma Center Hamburg

Summary

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Severe spinal cord injuries often result in tissue defects. Two possibilities are described to successfully bridge such gaps to promote tissue adaptation, regenerative responses and functional improvement in rats via implantation of a mechanical microconnector system after acute injury and five weeks after complete spinal cord transection.

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Brazda, N., Estrada, V., Voss, C., Seide, K., Trieu, H. K., Müller, H. W. Experimental Strategies to Bridge Large Tissue Gaps in the Injured Spinal Cord after Acute and Chronic Lesion. J. Vis. Exp. (110), e53331, doi:10.3791/53331 (2016).

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