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Bakım Glioblastoma Standardı Kapsamında Adoptif Tedavisi için CAR T hücrelerinin üretilmesi
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Inmunología y contagio
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JoVE Revista Inmunología y contagio
Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
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Bakım Glioblastoma Standardı Kapsamında Adoptif Tedavisi için CAR T hücrelerinin üretilmesi

21,104 Views

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12:55 min

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February 16, 2015

DOI:

10.3791/52397-v

DOI:
10.3791/52397-v

•

12:55 min
February 16, 2015

•

4 Views
, , , , ,
1Duke Brain Tumor Immunotherapy Program, Department of Neurosurgery,Duke University, 2Department of Biomedical Engineering,Duke University, 3Department of Pathology,Duke University

Summary

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The lymphodepletive and immunomodulatory effects of chemotherapy and radiation standard of care can be leveraged to enhance the antitumor efficacy of T cell immunotherapy. We outline a method for generating EGFRvIII-specific chimeric antigen receptor (CAR) T cells and administering them in the context of glioblastoma standard of care.

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CAR T CellsAdoptive ImmunotherapyGlioblastomaEGFRvIIIStandard Of CareTemozolomideWhole Brain Irradiation

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Cite this Article

Riccione, K., Suryadevara, C. M., Snyder, D., Cui, X., Sampson, J. H., Sanchez-Perez, L. Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care. J. Vis. Exp. (96), e52397, doi:10.3791/52397 (2015).

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