Most studies involving the Langendorff apparatus use small animal models due to the increased complexity of systems for larger mammals. We describe a Langendorff system for large animal models that allows for use across a range of species, including humans, and relatively easy data acquisition.
Schechter, M. A., Southerland, K. W., Feger, B. J., Linder Jr., D., Ali, A. A., Njoroge, L., Milano, C. A., Bowles, D. E. An Isolated Working Heart System for Large Animal Models. J. Vis. Exp. (88), e51671, doi:10.3791/51671 (2014).