We have developed a video-rate tracking microscope system that can record and quantify C. elegans behavior at high resolution and high speeds. We have also developed computational methods to reduce the dimensionality of the worm images to a fundamental set of measurements that completely describe the shape of the worm.
Likitlersuang, J., Stephens, G., Palanski, K., Ryu, W. S. C. elegans Tracking and Behavioral Measurement. J. Vis. Exp. (69), e4094, doi:10.3791/4094 (2012).