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A Quantitative Fitness Analysis Workflow
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August 13, 2012
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Quantitative Fitness Analysis (QFA) is a complementary series of experimental and computational methods for estimating microbial culture fitnesses. QFA estimates the effect of genetic mutations, drugs or other applied treatments on microbe growth. Experiments scaling from focussed analysis of single cultures to thousands of parallel cultures can be designed.
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Quantitative Fitness AnalysisQFAFitness ComparisonMicrobial CulturesGenetic InteractionDrug ScreensGrowth CurvesQuantitative Cell Density EstimatesFitness MeasuresGenetic Interaction StrengthsDrug SensitivitiesSubstrate AgarSmall MoleculesAntibioticsNutrientsUV IrradiationTemperatureGrowth Rate EstimatesSpectrophotometric MeasurementHigh Throughput
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Banks, A., Lawless, C., Lydall, D. A Quantitative Fitness Analysis Workflow. J. Vis. Exp. (66), e4018, doi:10.3791/4018 (2012).
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