The present report details the protocol employed to measure the rewarding effects of high-fat food in mice using a progressive ratio operant conditioning task.
Sharma, S., Hryhorczuk, C., Fulton, S. Progressive-ratio Responding for Palatable High-fat and High-sugar Food in Mice. J. Vis. Exp. (63), e3754, doi:10.3791/3754 (2012).