Journal
/
Inmunología y contagio
/
siRNA 전달을위한 셀 타입의 특정 안티 HIV gp120 aptamers의 개발
JoVE Revista
Inmunología y contagio
Se requiere una suscripción a JoVE para ver este contenido.  Inicie sesión o comience su prueba gratuita.
JoVE Revista Inmunología y contagio
Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery
Please note that all translations are automatically generated. Click here for the English version.

siRNA 전달을위한 셀 타입의 특정 안티 HIV gp120 aptamers의 개발

19,335 Views

•

13:47 min

•

June 23, 2011

DOI:

10.3791/2954-v

DOI:
10.3791/2954-v

•

13:47 min
June 23, 2011

•

5 Views
, , , ,
1Department of Molecular and Cellular Biology,Beckman Research Institute of City of Hope, 2Graduate School of Biological Sciences,Beckman Research Institute of City of Hope, 3Shared Resource-DNA/RNA Peptide,Beckman Research Institute of City of Hope

Summary

Automatically generated

nanomole 친화력과 HIV - 1Ba - L gp120에 대한 몇 가지 2' - 플루오로 RNA의 aptamers는 RNA 라이브러리에서에 의해 고립 아르<em> 체외에서</em> SELEX 절차. 키메라 새로운 듀얼 억제 기능을 방지 gp120 aptamer - siRNA가 생성되고 체계적 안티 HIV 치료를위한 상당한 약속을 보여줍니다.

Explore More Videos

Cell-type SpecificAnti-HIVGp120 AptamersSiRNA DeliveryHIV InfectionAntiretroviral AgentsSmall Interfering (si)RNAsTherapeuticsRNAi-basedHIV/AIDSRNA TranscriptsEfficient DeliveryTargeted Intracellular SiRNA Delivery ApproachHIV-1 Gp120 ProteinGlycoprotein EnvelopeViral EntryCD4 CellsAnti-viral StrategyDrug Discovery2′-F Modified Anti-HIV Gp120 RNA AptamersNitrocellulose Filter SELEX Method

Read Article

Cite this Article

Zhou, J., Li, H., Zhang, J., Piotr, S., Rossi, J. Development of Cell-type specific anti-HIV gp120 aptamers for siRNA delivery. J. Vis. Exp. (52), e2954, doi:10.3791/2954 (2011).

Download .ris file

Copy

Share Video

.

Copy