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Studying the Integration of Adult-born Neurons
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March 25, 2011
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A way to study the integration of newborn dentate granule cells in adult animals is described. This technique uses an engineered retrovirus to label newborn neurons, followed by electrophysiological recordings to determine in vivo functional integration.
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IntegrationAdult-born NeuronsNeurogenesisSub-ventricular ZoneLateral VentricleSub-granular ZoneHippocampal Dentate GyrusBrain DisordersEpilepsySchizophreniaDepressionAnxietyAberrant Neuron IntegrationEtiologyNew TherapiesFate SpecificationMigrationSynaptic IntegrationMaturationGABAergic InputGlutamatergic InputCircuit FormationDentate Granule CellsViral TechniqueCell Birth DateLineageMorphologySynaptogenesis
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Gu, Y., Janoschka, S., Ge, S. Studying the Integration of Adult-born Neurons. J. Vis. Exp. (49), e2548, doi:10.3791/2548 (2011).
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