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单克隆抗体的反对消极行政 H。 capsulatum和其他真菌病原体
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09:57 min
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February 14, 2011
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C57BL / 6小鼠已被用于研究HC发病机制，并提供最好的模式。我们正在探索这种真菌对体液免疫的潜在利益，并产生了几个单克隆抗体[组蛋白H2B和热休克蛋白60kDa]，我们为他们的腹腔给药后的保护效果测试。
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Passive AdministrationMonoclonal AntibodiesH. CapsulatumFungal PathogensHistoplasmosisAntibody TherapyVirulence FactorsMAbs GenerationSolid Phase ELISA SystemSplenocytes FusionC57BL/6 MiceInfection AssessmentMortality As An EndpointColony Forming Units (CFU)Survival StudiesIntervention EfficacyVaccine EfficacyVirulence Testing
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Guimarães, A. J., Martinez, L. R., Nosanchuk, J. D. Passive Administration of Monoclonal Antibodies Against H. capsulatum and Others Fungal Pathogens. J. Vis. Exp. (48), e2532, doi:10.3791/2532 (2011).
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