Journal
/
Neurociencias
/
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
JoVE Revista
Neurociencias
This content is Free Access.
JoVE Revista Neurociencias
Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology

93,369 Views

•

14:57 min

•

March 23, 2011

DOI:

10.3791/2330-v

DOI:
10.3791/2330-v

•

14:57 min
March 23, 2011

•

26 Views
, ,
1Graduate Center for Gerontology,University of Kentucky College of Public Health, 2Department of Molecular and Biomedical Pharmacology,University of Kentucky College of Medicine, 3Sanders-Brown Center on Aging,University of Kentucky College of Medicine

Summary

Automatically generated

This article outlines procedures for preparing hippocampal slices from rats and transgenic mice for the study of synaptic alterations associated with brain aging and age-related neurodegenerative diseases, such as Alzheimer’s disease.

Explore More Videos

Acute Hippocampal SlicesRatsTransgenic MiceSynaptic AlterationsAgingAmyloid PathologySynaptic FunctionPlasticityElectrophysiological TechniquesCognitive ImpairmentsSynaptic Plasticity MechanismsLong-term PotentiationLong-term DepressionNootropic CompoundsBrain AgingAlzheimer’s Disease (AD)Aged RatsAD Model Mice

Read Article

Cite this Article

Mathis, D. M., Furman, J. L., Norris, C. M. Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology. J. Vis. Exp. (49), e2330, doi:10.3791/2330 (2011).

Download .ris file

Copy

Share Video

.

Copy