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Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

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Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

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Bioquímica

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JoVE Revista Bioquímica

Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

Surface Plasmon Resonance (SPR) for Evaluating PROTACS-Induced Ternary Complex Formation

Characterization of Ternary Complex Formation in PROTACs Using Biophysical Assays

DOI:

10.3791/200656-v

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03:36 min

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January 12, 2024

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Wei Jiang, Holly Soutter

¹Center for the Development of Therapeutics,The Broad Institute of MIT and Harvard

Tags

Surface Plasmon Resonance (SPR)PROTACS Ternary Complex Formation VHL MZ1 BRD4 Binary Complex Ternary Complex Cooperativity Cereblon PPM1D Nickel NTA Chip Regeneration

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