3.19:
Drug Elimination by Renal Route: Glomerular Filtration
The kidney is the principal organ for the excretion of drugs and their metabolites. Renal elimination through urine begins with glomerular filtration.
Each kidney contains millions of nephrons. The nephron is the kidney's functional unit, where urine is formed. Each nephron contains a renal corpuscle and a renal tubule.
Drugs enter the kidney through the renal artery, which branches progressively and leads to the afferent arterioles.
The drug enters the glomerulus, surrounded by the Bowman's capsule, in the renal corpuscle portion of the nephron.
Since the glomerular capillaries' endothelium is fenestrated, the high blood pressure forces unbound drug molecules and other small solutes out of the glomerulus and into the Bowman's capsule in a process called glomerular filtration.
This fluid is the renal filtrate, which enters the renal tubule part of the nephron to form urine.
The glomerular filtration rate and the extent to which drugs bind to plasma proteins influence the amount of drugs entering the tubule.
Drugs not part of the filtrate exit the glomerulus through the efferent arterioles.
3.19:
Drug Elimination by Renal Route: Glomerular Filtration
The kidney serves as the primary organ responsible for eliminating drugs and their metabolites from the body. This process, known as renal elimination, starts with glomerular filtration and results in urine formation. Each kidney houses millions of functional units called nephrons, where urine production takes place. A nephron has two main components: a renal corpuscle and a renal tubule. Drugs gain access to the kidney via the renal artery, which progressively branches off into afferent arterioles. The drug then proceeds to the glomerulus, a network of capillaries enclosed by Bowman's capsule, located within the renal corpuscle section of the nephron. Due to the porous nature of the glomerular capillaries' endothelium and the elevated hydrostatic blood pressure inside the capillaries, unbound drug molecules, plasma, and other small solutes are pushed out of the glomerulus and into Bowman's capsule through a mechanism known as glomerular filtration. The resulting fluid, referred to as renal filtrate, moves into the renal tubule portion of the nephron, where it ultimately forms urine. Factors such as the glomerular filtration rate and the level of drug binding to plasma proteins determine the number of drugs that enter the tubule. Drugs not included in the filtrate leave the glomerulus via efferent arterioles.