Hans Clevers Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW) University Medical Center Utrecht Biography Publications Institution JoVE Articles Hans Clevers has not added a biography. If you are Hans Clevers and would like to personalize this page please email our Author Liaison for assistance. Publications Tubuloid Culture Enables Long-term Expansion of Functional Human Kidney Tubule Epithelium from IPSC-derived Organoids Proceedings of the National Academy of Sciences of the United States of America. Feb, 2023 | Pubmed ID: 36724260 Patient-derived Tumor Organoids Predict Responses to Irinotecan-based Neoadjuvant Chemoradiotherapy in Patients with Locally Advanced Rectal Cancer International Journal of Cancer. Feb, 2023 | Pubmed ID: 36161653 Uncovering the Mode of Action of Engineered T Cells in Patient Cancer Organoids Nature Biotechnology. Jan, 2023 | Pubmed ID: 35879361 Loss of LGR4/GPR48 Causes Severe Neonatal Salt-wasting Due to Disrupted WNT Signaling Altering Adrenal Zonation The Journal of Clinical Investigation. Dec, 2022 | Pubmed ID: 36538378 Rewiring Glucose Metabolism Improves 5-FU Efficacy in P53-deficient/KRAS Glycolytic Colorectal Tumors Communications Biology. Oct, 2022 | Pubmed ID: 36316440 Patient-Derived Organoids from Colorectal Cancer with Paired Liver Metastasis Reveal Tumor Heterogeneity and Predict Response to Chemotherapy Advanced Science (Weinheim, Baden-Wurttemberg, Germany). Nov, 2022 | Pubmed ID: 36058001 Differentiation and CRISPR-Cas9-mediated Genetic Engineering of Human Intestinal Organoids STAR Protocols. Sep, 2022 | Pubmed ID: 36042877 Optimized Human Intestinal Organoid Model Reveals Interleukin-22-dependency of Paneth Cell Formation Cell Stem Cell. Sep, 2022 | Pubmed ID: 36002022 Rapid Tissue Prototyping with Micro-organospheres Stem Cell Reports. Sep, 2022 | Pubmed ID: 35985334 A Bipotential Organoid Model of Respiratory Epithelium Recapitulates High Infectivity of SARS-CoV-2 Omicron Variant Cell Discovery. Jun, 2022 | Pubmed ID: 35710786 Patient-derived Micro-organospheres Enable Clinical Precision Oncology Cell Stem Cell. Jun, 2022 | Pubmed ID: 35508177 Functional Patient-derived Organoid Screenings Identify MCLA-158 As a Therapeutic EGFR × LGR5 Bispecific Antibody with Efficacy in Epithelial Tumors Nature Cancer. Apr, 2022 | Pubmed ID: 35469014 BMP Gradient Along the Intestinal Villus Axis Controls Zonated Enterocyte and Goblet Cell States Cell Reports. Mar, 2022 | Pubmed ID: 35235783 RNF43/ZNRF3 Negatively Regulates Taste Tissue Homeostasis and Positively Regulates Dorsal Lingual Epithelial Tissue Homeostasis Stem Cell Reports. Feb, 2022 | Pubmed ID: 34995498 Loss of Rnf43 Accelerates Kras-Mediated Neoplasia and Remodels the Tumor Immune Microenvironment in Pancreatic Adenocarcinoma Gastroenterology. Apr, 2022 | Pubmed ID: 34973294 Cancer Induces a Stress Ileopathy Depending on β-Adrenergic Receptors and Promoting Dysbiosis That Contributes to Carcinogenesis Cancer Discovery. Apr, 2022 | Pubmed ID: 34930787 Mycobacteria-host Interactions in Human Bronchiolar Airway Organoids Molecular Microbiology. Mar, 2022 | Pubmed ID: 34605588 Adult Mouse and Human Organoids Derived from Thyroid Follicular Cells and Modeling of Graves' Hyperthyroidism Proceedings of the National Academy of Sciences of the United States of America. Dec, 2021 | Pubmed ID: 34916298 Molecular Characterization of Barrett's Esophagus at Single-cell Resolution Proceedings of the National Academy of Sciences of the United States of America. Nov, 2021 | Pubmed ID: 34795059 The H3.3K27M Oncohistone Affects Replication Stress Outcome and Provokes Genomic Instability in Pediatric Glioma PLoS Genetics. Nov, 2021 | Pubmed ID: 34752469 A CRISPR/Cas9 Genetically Engineered Organoid Biobank Reveals Essential Host Factors for Coronaviruses Nature Communications. Sep, 2021 | Pubmed ID: 34535662 Single-cell Ribo-seq Reveals Cell Cycle-dependent Translational Pausing Nature. Sep, 2021 | Pubmed ID: 34497418 Intestinal Organoid Cocultures with Microbes Nature Protocols. Oct, 2021 | Pubmed ID: 34381208 Disease Modeling Following Organoid-based Expansion of Airway Epithelial Cells American Journal of Physiology. Lung Cellular and Molecular Physiology. Oct, 2021 | Pubmed ID: 34378410 Evidence Generation and Reproducibility in Cell and Gene Therapy Research: A Call to Action Molecular Therapy. Methods & Clinical Development. Sep, 2021 | Pubmed ID: 34377737 Evaluating CRISPR-based Prime Editing for Cancer Modeling and CFTR Repair in Organoids Life Science Alliance. Oct, 2021 | Pubmed ID: 34373320 Troy/Tnfrsf19 Marks Epidermal Cells That Govern Interfollicular Epidermal Renewal and Cornification Stem Cell Reports. Sep, 2021 | Pubmed ID: 34358453 Integration of Metabolomics, Genomics, and Immune Phenotypes Reveals the Causal Roles of Metabolites in Disease Genome Biology. Jul, 2021 | Pubmed ID: 34229738 Cysteamine-bicalutamide Combination Therapy Corrects Proximal Tubule Phenotype in Cystinosis EMBO Molecular Medicine. Jul, 2021 | Pubmed ID: 34165243 Organoids and Organs-on-chips: Insights into Human Gut-microbe Interactions Cell Host & Microbe. Jun, 2021 | Pubmed ID: 34111395 Patient-derived Organoids Model Cervical Tissue Dynamics and Viral Oncogenesis in Cervical Cancer Cell Stem Cell. Apr, 2021 | Pubmed ID: 33852917 Publisher Correction: LifeTime and Improving European Healthcare Through Cell-based Interceptive Medicine Nature. Apr, 2021 | Pubmed ID: 33731935 Exploring the Human Lacrimal Gland Using Organoids and Single-cell Sequencing Cell Stem Cell. Mar, 2021 | Pubmed ID: 33730555 The Organoid Platform: Promises and Challenges As Tools in the Fight Against COVID-19 Stem Cell Reports. 03, 2021 | Pubmed ID: 33691146 Human Gastrointestinal Epithelia of the Esophagus, Stomach, and Duodenum Resolved at Single-cell Resolution Cell Reports. Mar, 2021 | Pubmed ID: 33691112 Culture and Analysis of Kidney Tubuloids and Perfused Tubuloid Cells-on-a-chip Nature Protocols. 04, 2021 | Pubmed ID: 33674788 National Heart, Lung, and Blood Institute and Building Respiratory Epithelium and Tissue for Health (BREATH) Consortium Workshop Report: Moving Forward in Lung Regeneration American Journal of Respiratory Cell and Molecular Biology. Jul, 2021 | Pubmed ID: 33625958 Tissue Regeneration: Reserve or Reverse? Science (New York, N.Y.). Feb, 2021 | Pubmed ID: 33602845 Identification of Novel Human Wnt Target Genes Using Adult Endodermal Tissue-derived Organoids Developmental Biology. Jun, 2021 | Pubmed ID: 33571486 Derivation of Snake Venom Gland Organoids for in Vitro Venom Production Nature Protocols. 03, 2021 | Pubmed ID: 33504990 Single-cell Atlas of Developing Murine Adrenal Gland Reveals Relation of Schwann Cell Precursor Signature to Neuroblastoma Phenotype Proceedings of the National Academy of Sciences of the United States of America. Feb, 2021 | Pubmed ID: 33500353 Author Correction: Establishment of Patient-derived Cancer Organoids for Drug-screening Applications Nature Protocols. Jan, 2021 | Pubmed ID: 33437066 The Organoid Cell Atlas Nature Biotechnology. Jan, 2021 | Pubmed ID: 33384458 SIRT1 Inhibitors Mitigate Radiation-induced GI Syndrome by Enhancing Intestinal-stem-cell Survival Cancer Letters. Mar, 2021 | Pubmed ID: 33359449 An Organoid-derived Bronchioalveolar Model for SARS-CoV-2 Infection of Human Alveolar Type II-like Cells The EMBO Journal. Mar, 2021 | Pubmed ID: 33283287 Establishment of Human Fetal Hepatocyte Organoids and CRISPR-Cas9-based Gene Knockin and Knockout in Organoid Cultures from Human Liver Nature Protocols. 01, 2021 | Pubmed ID: 33247284 Cell Fate Specification and Differentiation in the Adult Mammalian Intestine Nature Reviews. Molecular Cell Biology. 01, 2021 | Pubmed ID: 32958874 Human Extrahepatic and Intrahepatic Cholangiocyte Organoids Show Region-specific Differentiation Potential and Model Cystic Fibrosis-related Bile Duct Disease Scientific Reports. Dec, 2020 | Pubmed ID: 33318612 Author Correction: Fasting-mimicking Diet and Hormone Therapy Induce Breast Cancer Regression Nature. Dec, 2020 | Pubmed ID: 33273708 Translation and Replication Dynamics of Single RNA Viruses Cell. Dec, 2020 | Pubmed ID: 33188777 CRISPR-Cas Tools and Their Application in Genetic Engineering of Human Stem Cells and Organoids Cell Stem Cell. Nov, 2020 | Pubmed ID: 33157047 Single-cell Derived Tumor Organoids Display Diversity in HLA Class I Peptide Presentation Nature Communications. Oct, 2020 | Pubmed ID: 33087703 A Human Organoid Model of Aggressive Hepatoblastoma for Disease Modeling and Drug Testing Cancers. Sep, 2020 | Pubmed ID: 32962010 Establishment of Patient-derived Cancer Organoids for Drug-screening Applications Nature Protocols. 10, 2020 | Pubmed ID: 32929210 Deficiency of the SMOC2 Matricellular Protein Impairs Bone Healing and Produces Age-dependent Bone Loss Scientific Reports. Sep, 2020 | Pubmed ID: 32908163 LifeTime and Improving European Healthcare Through Cell-based Interceptive Medicine Nature. 11, 2020 | Pubmed ID: 32894860 Human-Derived Model Systems in Gynecological Cancer Research Trends in Cancer. 12, 2020 | Pubmed ID: 32855097 Intestinal Regeneration: Regulation by the Microenvironment Developmental Cell. 08, 2020 | Pubmed ID: 32841594 Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo Cell Stem Cell. Nov, 2020 | Pubmed ID: 32818433 Mathematical Model of Colorectal Cancer Initiation Proceedings of the National Academy of Sciences of the United States of America. 08, 2020 | Pubmed ID: 32788368 Primary Intestinal Epithelial Organoid Culture Methods in Molecular Biology (Clifton, N.J.). 2020 | Pubmed ID: 32705642 Fasting-mimicking Diet and Hormone Therapy Induce Breast Cancer Regression Nature. Jul, 2020 | Pubmed ID: 32669709 Patient-Derived Ovarian Cancer Organoids Mimic Clinical Response and Exhibit Heterogeneous Inter- and Intrapatient Drug Responses Cell Reports. Jun, 2020 | Pubmed ID: 32553164 COVID-19: Organoids Go Viral Nature Reviews. Molecular Cell Biology. 07, 2020 | Pubmed ID: 32483314 Kidney Organoids and Tubuloids Cells. May, 2020 | Pubmed ID: 32466429 Assessing the Origin of High-grade Serous Ovarian Cancer Using CRISPR-modification of Mouse Organoids Nature Communications. 05, 2020 | Pubmed ID: 32461556 Patient-derived Pancreatic Tumour Organoids Identify Therapeutic Responses to Oncolytic Adenoviruses EBioMedicine. Jun, 2020 | Pubmed ID: 32460166 High-Resolution MRNA and Secretome Atlas of Human Enteroendocrine Cells Cell. 06, 2020 | Pubmed ID: 32407674 Challenges in Establishing Pure Lung Cancer Organoids Limit Their Utility for Personalized Medicine Cell Reports. May, 2020 | Pubmed ID: 32375033 SARS-CoV-2 Productively Infects Human Gut Enterocytes Science (New York, N.Y.). 07, 2020 | Pubmed ID: 32358202 The Potential and Challenges of Patient-derived Organoids in Guiding the Multimodality Treatment of Upper Gastrointestinal Malignancies Open Biology. Apr, 2020 | Pubmed ID: 32259456 Sequencing Metabolically Labeled Transcripts in Single Cells Reveals MRNA Turnover Strategies Science (New York, N.Y.). Mar, 2020 | Pubmed ID: 32139547 Fast and Efficient Generation of Knock-in Human Organoids Using Homology-independent CRISPR-Cas9 Precision Genome Editing Nature Cell Biology. Mar, 2020 | Pubmed ID: 32123335 Mutational Signature in Colorectal Cancer Caused by Genotoxic Pks E. Coli Nature. Apr, 2020 | Pubmed ID: 32106218 Conformation-specific Inhibitors of Activated Ras GTPases Reveal Limited Ras Dependency of Patient-derived Cancer Organoids The Journal of Biological Chemistry. Apr, 2020 | Pubmed ID: 32086379 CRISPR-Based Adenine Editors Correct Nonsense Mutations in a Cystic Fibrosis Organoid Biobank Cell Stem Cell. Apr, 2020 | Pubmed ID: 32084388 Long-Term Survival of Transplanted Autologous Canine Liver Organoids in a -Deficient Dog Model of Metabolic Liver Disease Cells. Feb, 2020 | Pubmed ID: 32053895 Snake Venom Gland Organoids Cell. Jan, 2020 | Pubmed ID: 31978343 LKB1 Represses ATOH1 Via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate Gastroenterology. Apr, 2020 | Pubmed ID: 31930988 Very Early Onset Inflammatory Bowel Disease: A Clinical Approach With a Focus on the Role of Genetics and Underlying Immune Deficiencies Inflammatory Bowel Diseases. 05, 2020 | Pubmed ID: 31833544 Patient-Derived Organoids Predict Chemoradiation Responses of Locally Advanced Rectal Cancer Cell Stem Cell. Jan, 2020 | Pubmed ID: 31761724 Large-Scale Production of LGR5-Positive Bipotential Human Liver Stem Cells Hepatology (Baltimore, Md.). Jul, 2020 | Pubmed ID: 31715015 Organoids: Avatars for Personalized Medicine The Keio Journal of Medicine. 2019 | Pubmed ID: 31875622 Pancreatic Cancer Organoids Recapitulate Disease and Allow Personalized Drug Screening Proceedings of the National Academy of Sciences of the United States of America. Dec, 2019 | Pubmed ID: 31818951 Patient-Derived Head and Neck Cancer Organoids Recapitulate EGFR Expression Levels of Respective Tissues and Are Responsive to EGFR-Targeted Photodynamic Therapy Journal of Clinical Medicine. Nov, 2019 | Pubmed ID: 31694307 Defining the Identity and Dynamics of Adult Gastric Isthmus Stem Cells Cell Stem Cell. Sep, 2019 | Pubmed ID: 31422913 A Versatile Biosynthetic Hydrogel Platform for Engineering of Tissue Analogues Advanced Healthcare Materials. Oct, 2019 | Pubmed ID: 31402634 Xenograft and Organoid Model Systems in Cancer research The EMBO Journal. 08, 2019 | Pubmed ID: 31282586 T Cell Recruitment to the Intestinal Stem Cell Compartment Drives Immune-Mediated Intestinal Damage After Allogeneic Transplantation Immunity. Jul, 2019 | Pubmed ID: 31278057 Long-term Expansion and Differentiation of Adult Murine Epidermal Stem Cells in 3D Organoid Cultures Proceedings of the National Academy of Sciences of the United States of America. Jul, 2019 | Pubmed ID: 31253707 Probing the Tumor Suppressor Function of BAP1 in CRISPR-Engineered Human Liver Organoids Cell Stem Cell. Jun, 2019 | Pubmed ID: 31130514 High-resolution 3D Imaging of Fixed and Cleared Organoids Nature Protocols. 06, 2019 | Pubmed ID: 31053799 Oral Mucosal Organoids As a Potential Platform for Personalized Cancer Therapy Cancer Discovery. 07, 2019 | Pubmed ID: 31053628 An Organoid Platform for Ovarian Cancer Captures Intra- and Interpatient Heterogeneity Nature Medicine. May, 2019 | Pubmed ID: 31011202 Tubuloids Derived from Human Adult Kidney and Urine for Personalized Disease Modeling Nature Biotechnology. 03, 2019 | Pubmed ID: 30833775 Mouse and Human Urothelial Cancer Organoids: A Tool for Bladder Cancer Research Proceedings of the National Academy of Sciences of the United States of America. Mar, 2019 | Pubmed ID: 30787188 Rectal Organoids Enable Personalized Treatment of Cystic Fibrosis Cell Reports. Feb, 2019 | Pubmed ID: 30759382 Modeling Human Digestive Diseases With CRISPR-Cas9-Modified Organoids Gastroenterology. Feb, 2019 | Pubmed ID: 30476497 Intestinal Inflammation and Dysregulated Immunity in Patients With Inherited Caspase-8 Deficiency Gastroenterology. 01, 2019 | Pubmed ID: 30267714 Profiling Proliferative Cells and Their Progeny in Damaged Murine Hearts Proceedings of the National Academy of Sciences of the United States of America. 12, 2018 | Pubmed ID: 30530645 Long-Term Expansion of Functional Mouse and Human Hepatocytes As 3D Organoids Cell. 11, 2018 | Pubmed ID: 30500538 Paneth Cells Respond to Inflammation and Contribute to Tissue Regeneration by Acquiring Stem-like Features Through SCF/c-Kit Signaling Cell Reports. Aug, 2018 | Pubmed ID: 30157426 Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids Cell. Sep, 2018 | Pubmed ID: 30100188 Enteroendocrine Cells Switch Hormone Expression Along the Crypt-to-villus BMP Signalling Gradient Nature Cell Biology. Aug, 2018 | Pubmed ID: 30038251 Tropism, Replication Competence, and Innate Immune Responses of Influenza Virus: an Analysis of Human Airway Organoids and Ex-vivo Bronchus Cultures The Lancet. Respiratory Medicine. Nov, 2018 | Pubmed ID: 30001996 Modelling Cryptosporidium Infection in Human Small Intestinal and Lung Organoids Nature Microbiology. 07, 2018 | Pubmed ID: 29946163 Bioengineered Bile Ducts Recapitulate Key Cholangiocyte Functions Biofabrication. Jun, 2018 | Pubmed ID: 29848792 Use and Application of 3D-organoid Technology Human Molecular Genetics. Aug, 2018 | Pubmed ID: 29796608 Notch Ligand Dll1 Mediates Cross-talk Between Mammary Stem Cells and the Macrophageal Niche Science (New York, N.Y.). Jun, 2018 | Pubmed ID: 29773667 Hematopoietic Stem Cells Can Differentiate into Restricted Myeloid Progenitors Before Cell Division in Mice Nature Communications. May, 2018 | Pubmed ID: 29765026 Enterovirus 71 Infection of Human Airway Organoids Reveals VP1-145 As a Viral Infectivity Determinant Emerging Microbes & Infections. May, 2018 | Pubmed ID: 29743570 Intra-tumour Diversification in Colorectal Cancer at the Single-cell Level Nature. Apr, 2018 | Pubmed ID: 29643510 Expansion of Adult Human Pancreatic Tissue Yields Organoids Harboring Progenitor Cells with Endocrine Differentiation Potential Stem Cell Reports. Mar, 2018 | Pubmed ID: 29539434 Defining Adult Stem Cells by Function, Not by Phenotype Annual Review of Biochemistry. Jun, 2018 | Pubmed ID: 29494240 Troy+ Brain Stem Cells Cycle Through Quiescence and Regulate Their Number by Sensing Niche Occupancy Proceedings of the National Academy of Sciences of the United States of America. Jan, 2018 | Pubmed ID: 29311336 Imaging Organoids: a Bright Future Ahead Nature Methods. Jan, 2018 | Pubmed ID: 29298292 A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity Cell. Jan, 2018 | Pubmed ID: 29224780 Measuring Mutation Accumulation in Single Human Adult Stem Cells by Whole-genome Sequencing of Organoid Cultures Nature Protocols. Jan, 2018 | Pubmed ID: 29215633 Syndecan-1 Promotes Wnt/β-catenin Signaling in Multiple Myeloma by Presenting Wnts and R-spondins Blood. Mar, 2018 | Pubmed ID: 29212806 A Single-Cell RNA Sequencing Study Reveals Cellular and Molecular Dynamics of the Hippocampal Neurogenic Niche Cell Reports. Dec, 2017 | Pubmed ID: 29241552 Troy/TNFRSF19 Marks Epithelial Progenitor Cells During Mouse Kidney Development That Continue to Contribute to Turnover in Adult Kidney Proceedings of the National Academy of Sciences of the United States of America. Dec, 2017 | Pubmed ID: 29237753 The Human Cell Atlas ELife. 12, 2017 | Pubmed ID: 29206104 Cancer Stem Cells Revisited Nature Medicine. Oct, 2017 | Pubmed ID: 28985214 MET Signaling Mediates Intestinal Crypt-Villus Development, Regeneration, and Adenoma Formation and Is Promoted by Stem Cell CD44 Isoforms Gastroenterology. Oct, 2017 | Pubmed ID: 28716720 Wnt/β-Catenin Signaling, Disease, and Emerging Therapeutic Modalities Cell. Jun, 2017 | Pubmed ID: 28575679 Oncogene-inducible Organoids As a Miniature Platform to Assess Cancer Characteristics The Journal of Cell Biology. Jun, 2017 | Pubmed ID: 28512141 SCA-1 Expression Level Identifies Quiescent Hematopoietic Stem and Progenitor Cells Stem Cell Reports. Jun, 2017 | Pubmed ID: 28506535 Surrogate Wnt Agonists That Phenocopy Canonical Wnt and β-catenin Signalling Nature. May, 2017 | Pubmed ID: 28467818 Disease Modeling in Stem Cell-Derived 3D Organoid Systems Trends in Molecular Medicine. May, 2017 | Pubmed ID: 28341301 Intestinal Epithelial Organoids Fuse to Form Self-organizing Tubes in Floating Collagen Gels Development (Cambridge, England). 03, 2017 | Pubmed ID: 28292848 Lipid-mediated Wnt Protein Stabilization Enables Serum-free Culture of Human Organ Stem Cells Nature Communications. Mar, 2017 | Pubmed ID: 28262686 WNT Signalling Events Near the Cell Membrane and Their Pharmacological Targeting for the Treatment of Cancer British Journal of Pharmacology. Dec, 2017 | Pubmed ID: 28244067 Converging Biofabrication and Organoid Technologies: the Next Frontier in Hepatic and Intestinal Tissue Engineering? Biofabrication. Mar, 2017 | Pubmed ID: 28211365 CRISPR/Cas 9 Genome Editing and Its Applications in Organoids American Journal of Physiology. Gastrointestinal and Liver Physiology. Jan, 2017 | Pubmed ID: 28126704 Interrogating Open Issues in Cancer Precision Medicine with Patient-derived Xenografts Nature Reviews. Cancer. 01, 2017 | Pubmed ID: 28104906 Human Tissues in a Dish: The Research and Ethical Implications of Organoid Technology Science (New York, N.Y.). Jan, 2017 | Pubmed ID: 28104841 Erratum: Programs for the Persistence, Vigilance and Control of Human CD8(+) Lung-resident Memory T Cells Nature Immunology. Jan, 2017 | Pubmed ID: 28102212 Personalized Proteome Profiles of Healthy and Tumor Human Colon Organoids Reveal Both Individual Diversity and Basic Features of Colorectal Cancer Cell Reports. Jan, 2017 | Pubmed ID: 28052255 Aberrantly Expressed LGR4 Empowers Wnt Signaling in Multiple Myeloma by Hijacking Osteoblast-derived R-spondins Proceedings of the National Academy of Sciences of the United States of America. Jan, 2017 | Pubmed ID: 28028233 Induced Quiescence of Lgr5+ Stem Cells in Intestinal Organoids Enables Differentiation of Hormone-Producing Enteroendocrine Cells Cell Stem Cell. Feb, 2017 | Pubmed ID: 27939219 Genome-wide CRISPR Screens Reveal a Wnt-FZD5 Signaling Circuit As a Druggable Vulnerability of RNF43-mutant Pancreatic Tumors Nature Medicine. Jan, 2017 | Pubmed ID: 27869803 IκBNS Enhances Follicular Helper T-cell Differentiation and Function Downstream of ASCl2 The Journal of Allergy and Clinical Immunology. Dec, 2016 | Pubmed ID: 28040417 Designer Matrices for Intestinal Stem Cell and Organoid Culture Nature. Nov, 2016 | Pubmed ID: 27851739 Targeting Mutant RAS in Patient-derived Colorectal Cancer Organoids by Combinatorial Drug Screening ELife. Nov, 2016 | Pubmed ID: 27845624 Regulation and Plasticity of Intestinal Stem Cells During Homeostasis and Regeneration Development (Cambridge, England). Oct, 2016 | Pubmed ID: 27802133 Programs for the Persistence, Vigilance and Control of Human CD8(+) Lung-resident Memory T Cells Nature Immunology. Dec, 2016 | Pubmed ID: 27776108 Generation of an Inducible Colon-specific Cre Enzyme Mouse Line for Colon Cancer Research Proceedings of the National Academy of Sciences of the United States of America. Oct, 2016 | Pubmed ID: 27708166 Tissue-specific Mutation Accumulation in Human Adult Stem Cells During Life Nature. Oct, 2016 | Pubmed ID: 27698416 Organoids: Modeling Development and the Stem Cell Niche in a Dish Developmental Cell. Sep, 2016 | Pubmed ID: 27676432 The Generation of Organoids for Studying Wnt Signaling Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27590160 Reg4+ Deep Crypt Secretory Cells Function As Epithelial Niche for Lgr5+ Stem Cells in Colon Proceedings of the National Academy of Sciences of the United States of America. Sep, 2016 | Pubmed ID: 27573849 Culture and Establishment of Self-renewing Human and Mouse Adult Liver and Pancreas 3D Organoids and Their Genetic Manipulation Nature Protocols. Sep, 2016 | Pubmed ID: 27560176 Inactivation of TGFβ Receptors in Stem Cells Drives Cutaneous Squamous Cell Carcinoma Nature Communications. Aug, 2016 | Pubmed ID: 27558455 Who Is in the Driver's Seat: Tracing Cancer Genes Using CRISPR-Barcoding Molecular Cell. Aug, 2016 | Pubmed ID: 27494556 Analysis of Neural Crest-derived Clones Reveals Novel Aspects of Facial Development Science Advances. Aug, 2016 | Pubmed ID: 27493992 De Novo Prediction of Stem Cell Identity Using Single-Cell Transcriptome Data Cell Stem Cell. Aug, 2016 | Pubmed ID: 27345837 Characterizing Responses to CFTR-modulating Drugs Using Rectal Organoids Derived from Subjects with Cystic Fibrosis Science Translational Medicine. Jun, 2016 | Pubmed ID: 27334259 RNF43 Germline and Somatic Mutation in Serrated Neoplasia Pathway and Its Association with BRAF Mutation Gut. Jun, 2016 | Pubmed ID: 27329244 Modeling Development and Disease with Organoids Cell. Jun, 2016 | Pubmed ID: 27315476 Model Organoids Provide New Research Opportunities for Ductal Pancreatic Cancer Molecular & Cellular Oncology. Jan, 2016 | Pubmed ID: 27308531 Organoid Biobanking: Identifying the Ethics: Organoids Revive Old and Raise New Ethical Challenges for Basic Research and Therapeutic Use EMBO Reports. Jul, 2016 | Pubmed ID: 27296278 CRISPR/Cas9-Mediated Genome Editing of Mouse Small Intestinal Organoids Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27246017 TGFβ Signaling Directs Serrated Adenomas to the Mesenchymal Colorectal Cancer Subtype EMBO Molecular Medicine. Jul, 2016 | Pubmed ID: 27221051 Mule Regulates the Intestinal Stem Cell Niche Via the Wnt Pathway and Targets EphB3 for Proteasomal and Lysosomal Degradation Cell Stem Cell. Aug, 2016 | Pubmed ID: 27184401 Modeling Pancreatic Cancer with Organoids Trends in Cancer. Apr, 2016 | Pubmed ID: 27135056 Tissue-specific Designs of Stem Cell Hierarchies Nature Cell Biology. Apr, 2016 | Pubmed ID: 26999737 Dual Regulatory Switch Through Interactions of Tcf7l2/Tcf4 with Stage-specific Partners Propels Oligodendroglial Maturation Nature Communications. Mar, 2016 | Pubmed ID: 26955760 Generation and Characterization of Rat Liver Stem Cell Lines and Their Engraftment in a Rat Model of Liver Failure Scientific Reports. Feb, 2016 | Pubmed ID: 26915950 Visualization of a Short-range Wnt Gradient in the Intestinal Stem-cell Niche Nature. Feb, 2016 | Pubmed ID: 26863187 Replacement of Lost Lgr5-Positive Stem Cells Through Plasticity of Their Enterocyte-Lineage Daughters Cell Stem Cell. Feb, 2016 | Pubmed ID: 26831517 Organoid Culture Systems for Prostate Epithelial and Cancer Tissue Nature Protocols. Feb, 2016 | Pubmed ID: 26797458 Reparative Inflammation Takes Charge of Tissue Regeneration Nature. Jan, 2016 | Pubmed ID: 26791721 Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals Stem Cell Reports. Jan, 2016 | Pubmed ID: 26724906 STEM CELLS. What is an Adult Stem Cell? Science (New York, N.Y.). Dec, 2015 | Pubmed ID: 26659043 Identification of Different Classes of Luminal Progenitor Cells Within Prostate Tumors Cell Reports. Dec, 2015 | Pubmed ID: 26628377 Dynamics of Lgr6⁺ Progenitor Cells in the Hair Follicle, Sebaceous Gland, and Interfollicular Epidermis Stem Cell Reports. Nov, 2015 | Pubmed ID: 26607954 The Gut Microbiota Keeps Enteric Glial Cells on the Move; Prospective Roles of the Gut Epithelium and Immune System Gut Microbes. 2015 | Pubmed ID: 26558327 Radical Sabbaticals Cell. Nov, 2015 | Pubmed ID: 26544929 Preserved Genetic Diversity in Organoids Cultured from Biopsies of Human Colorectal Cancer Metastases Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26460009 Disease Modeling and Gene Therapy of Copper Storage Disease in Canine Hepatic Organoids Stem Cell Reports. Oct, 2015 | Pubmed ID: 26455412 Pre-clinical Models of Pancreatic Ductal Adenocarcinoma The Journal of Pathology. Sep, 2015 | Pubmed ID: 26419819 An Inducible Mouse Model for Microvillus Inclusion Disease Reveals a Role for Myosin Vb in Apical and Basolateral Trafficking Proceedings of the National Academy of Sciences of the United States of America. Oct, 2015 | Pubmed ID: 26392529 Lgr4 Controls Specialization of Female Gonads in Mice Biology of Reproduction. Oct, 2015 | Pubmed ID: 26333992 Single-cell Messenger RNA Sequencing Reveals Rare Intestinal Cell Types Nature. Sep, 2015 | Pubmed ID: 26287467 In Situ Hybridization to Identify Gut Stem Cells Current Protocols in Stem Cell Biology. 2015 | Pubmed ID: 26237569 Development and Application of Human Adult Stem or Progenitor Cell Organoids Nature Reviews. Nephrology. Sep, 2015 | Pubmed ID: 26215513 Expanding Intestinal Stem Cells in Culture Cell Research. Sep, 2015 | Pubmed ID: 26169607 SnapShot: Growing Organoids from Stem Cells Cell. Jun, 2015 | Pubmed ID: 26091044 Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer Cell. Jun, 2015 | Pubmed ID: 26091037 Porcupine Inhibitor Suppresses Paracrine Wnt-driven Growth of Rnf43;Znrf3-mutant Neoplasia Proceedings of the National Academy of Sciences of the United States of America. Jun, 2015 | Pubmed ID: 26023187 Repairing Organs: Lessons from Intestine and Liver Trends in Genetics : TIG. Jun, 2015 | Pubmed ID: 25989898 Q&A: Hans Clevers. Banking on Organoids Nature. May, 2015 | Pubmed ID: 25970453 Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients Cell. May, 2015 | Pubmed ID: 25957691 Sequential Cancer Mutations in Cultured Human Intestinal Stem Cells Nature. May, 2015 | Pubmed ID: 25924068 Efficient Intracellular Delivery of Native Proteins Cell. Apr, 2015 | Pubmed ID: 25910214 Frizzled7 Functions As a Wnt Receptor in Intestinal Epithelial Lgr5(+) Stem Cells Stem Cell Reports. May, 2015 | Pubmed ID: 25892522 An EphB-Abl Signaling Pathway is Associated with Intestinal Tumor Initiation and Growth Science Translational Medicine. Apr, 2015 | Pubmed ID: 25834110 Premigratory and Migratory Neural Crest Cells Are Multipotent in Vivo Cell Stem Cell. Mar, 2015 | Pubmed ID: 25748934 Germline Deletions in the Tumour Suppressor Gene FOCAD Are Associated with Polyposis and Colorectal Cancer Development The Journal of Pathology. Jun, 2015 | Pubmed ID: 25712196 Generation and Analysis of Mouse Intestinal Tumors and Organoids Harboring APC and K-Ras Mutations Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 25636467 Ascl2 Acts As an R-spondin/Wnt-responsive Switch to Control Stemness in Intestinal Crypts Cell Stem Cell. Feb, 2015 | Pubmed ID: 25620640 Microbiota Controls the Homeostasis of Glial Cells in the Gut Lamina Propria Neuron. Jan, 2015 | Pubmed ID: 25578362 Organoid Models of Human and Mouse Ductal Pancreatic Cancer Cell. Jan, 2015 | Pubmed ID: 25557080 Long-term Culture of Genome-stable Bipotent Stem Cells from Adult Human Liver Cell. Jan, 2015 | Pubmed ID: 25533785 Targeting Development of Incretin-producing Cells Increases Insulin Secretion The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500886 Plasticity Within Stem Cell Hierarchies in Mammalian Epithelia Trends in Cell Biology. Feb, 2015 | Pubmed ID: 25308311 In Vitro Expansion of Human Gastric Epithelial Stem Cells and Their Responses to Bacterial Infection Gastroenterology. Jan, 2015 | Pubmed ID: 25307862 Transformation of Intestinal Stem Cells into Gastric Stem Cells on Loss of Transcription Factor Cdx2 Nature Communications. 2014 | Pubmed ID: 25500896 Large-scale Identification of Coregulated Enhancer Networks in the Adult Human Brain Cell Reports. Oct, 2014 | Pubmed ID: 25373911 Stem Cell Signaling. An Integral Program for Tissue Renewal and Regeneration: Wnt Signaling and Stem Cell Control Science (New York, N.Y.). Oct, 2014 | Pubmed ID: 25278615 A20 Controls Intestinal Homeostasis Through Cell-specific Activities Nature Communications. 2014 | Pubmed ID: 25267258 Robust Cre-mediated Recombination in Small Intestinal Stem Cells Utilizing the Olfm4 Locus Stem Cell Reports. Aug, 2014 | Pubmed ID: 25254337 Inducible in Vivo Silencing of Brd4 Identifies Potential Toxicities of Sustained BET Protein Inhibition Cell Reports. Sep, 2014 | Pubmed ID: 25242322 Organoid Cultures Derived from Patients with Advanced Prostate Cancer Cell. Sep, 2014 | Pubmed ID: 25201530 Identification of Multipotent Luminal Progenitor Cells in Human Prostate Organoid Cultures Cell. Sep, 2014 | Pubmed ID: 25201529 Immune Deficiency-related Enteropathy-lymphocytopenia-alopecia Syndrome Results from Tetratricopeptide Repeat Domain 7A Deficiency The Journal of Allergy and Clinical Immunology. Dec, 2014 | Pubmed ID: 25174867 Mapping Early Fate Determination in Lgr5+ Crypt Stem Cells Using a Novel Ki67-RFP Allele The EMBO Journal. Sep, 2014 | Pubmed ID: 25092767 Glial Origin of Mesenchymal Stem Cells in a Tooth Model System Nature. Sep, 2014 | Pubmed ID: 25079316 Genome Sequencing of Normal Cells Reveals Developmental Lineages and Mutational Processes Nature. Sep, 2014 | Pubmed ID: 25043003 Paneth Cell Extrusion and Release of Antimicrobial Products is Directly Controlled by Immune Cell-derived IFN-γ The Journal of Experimental Medicine. Jun, 2014 | Pubmed ID: 24980747 Leucine-rich Repeat-containing G-protein-coupled Receptor 5 Marks Short-term Hematopoietic Stem and Progenitor Cells During Mouse Embryonic Development The Journal of Biological Chemistry. Aug, 2014 | Pubmed ID: 24966324 Paneth Cells Current Biology : CB. Jun, 2014 | Pubmed ID: 24937274 Human Intestinal Tissue with Adult Stem Cell Properties Derived from Pluripotent Stem Cells Stem Cell Reports. Jun, 2014 | Pubmed ID: 24936470 Polarizing Intestinal Epithelial Cells Electrically Through Ror2 Journal of Cell Science. Aug, 2014 | Pubmed ID: 24928904 Stem Cells Marked by the R-Spondin Receptor LGR5 Gastroenterology. Aug, 2014 | Pubmed ID: 24859206 Whole-genome Sequencing and Comprehensive Molecular Profiling Identify New Driver Mutations in Gastric Cancer Nature Genetics. Jun, 2014 | Pubmed ID: 24816253 Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease Gastroenterology. Jul, 2014 | Pubmed ID: 24726755 Selection of Personalized Patient Therapy Through the Use of Knowledge-based Computational Models That Identify Tumor-driving Signal Transduction Pathways Cancer Research. Jun, 2014 | Pubmed ID: 24695361 A Promoter-level Mammalian Expression Atlas Nature. Mar, 2014 | Pubmed ID: 24670764 Organoid Cultures for the Analysis of Cancer Phenotypes Current Opinion in Genetics & Development. Feb, 2014 | Pubmed ID: 24657539 KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells Cancer Research. May, 2014 | Pubmed ID: 24626089 STRAD Pseudokinases Regulate Axogenesis and LKB1 Stability Neural Development. 2014 | Pubmed ID: 24594058 The R-spondin/Lgr5/Rnf43 Module: Regulator of Wnt Signal Strength Genes & Development. Feb, 2014 | Pubmed ID: 24532711 Intestinal Crypt Homeostasis Revealed at Single-stem-cell Level by in Vivo Live Imaging Nature. Mar, 2014 | Pubmed ID: 24531760 Adult Stem Cells in the Small Intestine Are Intrinsically Programmed with Their Location-specific Function Stem Cells (Dayton, Ohio). May, 2014 | Pubmed ID: 24496776 Ovarian LGR5 is Critical for Successful Pregnancy FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2014 | Pubmed ID: 24469993 Transcription Factor Achaete-scute Homologue 2 Initiates Follicular T-helper-cell Development Nature. Mar, 2014 | Pubmed ID: 24463518 Wnt-induced Transcriptional Activation is Exclusively Mediated by TCF/LEF The EMBO Journal. Jan, 2014 | Pubmed ID: 24413017 Biased Competition Between Lgr5 Intestinal Stem Cells Driven by Oncogenic Mutation Induces Clonal Expansion EMBO Reports. Jan, 2014 | Pubmed ID: 24355609 Many Inflammatory Bowel Disease Risk Loci Include Regions That Regulate Gene Expression in Immune Cells and the Intestinal Epithelium Gastroenterology. Apr, 2014 | Pubmed ID: 24333384 TTC7A Mutations Disrupt Intestinal Epithelial Apicobasal Polarity The Journal of Clinical Investigation. Jan, 2014 | Pubmed ID: 24292712 Niche-independent High-purity Cultures of Lgr5+ Intestinal Stem Cells and Their Progeny Nature Methods. Jan, 2014 | Pubmed ID: 24292484 LGR5 Positivity Defines Stem-like Cells in Colorectal Cancer Carcinogenesis. Apr, 2014 | Pubmed ID: 24282287 Generation of L Cells in Mouse and Human Small Intestine Organoids Diabetes. Feb, 2014 | Pubmed ID: 24130334 Occult Progression by Apc-deficient Intestinal Crypts As a Target for Chemoprevention Carcinogenesis. Jan, 2014 | Pubmed ID: 23996931 Retroviral Gene Expression Control in Primary Organoid Cultures Current Protocols in Stem Cell Biology. 2013 | Pubmed ID: 24510288 Structures of Wnt-antagonist ZNRF3 and Its Complex with R-spondin 1 and Implications for Signaling PloS One. 2013 | Pubmed ID: 24349440 Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients Cell Stem Cell. Dec, 2013 | Pubmed ID: 24315439 Generation of BAC Transgenic Epithelial Organoids PloS One. 2013 | Pubmed ID: 24204693 Retromer Dependent Recycling of the Wnt Secretion Factor Wls is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium PloS One. 2013 | Pubmed ID: 24130821 Differentiated Troy+ Chief Cells Act As Reserve Stem Cells to Generate All Lineages of the Stomach Epithelium Cell. Oct, 2013 | Pubmed ID: 24120136 A Gutsy Approach to Stem Cells and Signalling: an Interview with Hans Clevers Disease Models & Mechanisms. Sep, 2013 | Pubmed ID: 24046385 Unlimited in Vitro Expansion of Adult Bi-potent Pancreas Progenitors Through the Lgr5/R-spondin Axis The EMBO Journal. Oct, 2013 | Pubmed ID: 24045232 LGR4 Expressed in Uterine Epithelium is Necessary for Uterine Gland Development and Contributes to Decidualization in Mice FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2013 | Pubmed ID: 23975934 The Intestinal Crypt, a Prototype Stem Cell Compartment Cell. Jul, 2013 | Pubmed ID: 23870119 Amplification of Progenitors in the Mammalian Telencephalon Includes a New Radial Glial Cell Type Nature Communications. 2013 | Pubmed ID: 23839311 Concise Review: the Yin and Yang of Intestinal (cancer) Stem Cells and Their Progenitors Stem Cells (Dayton, Ohio). Nov, 2013 | Pubmed ID: 23836510 Lgr5(+) Liver Stem Cells, Hepatic Organoids and Regenerative Medicine Regenerative Medicine. Jul, 2013 | Pubmed ID: 23826690 Structure of Stem Cell Growth Factor R-spondin 1 in Complex with the Ectodomain of Its Receptor LGR5 Cell Reports. Jun, 2013 | Pubmed ID: 23809763 Growing Self-organizing Mini-guts from a Single Intestinal Stem Cell: Mechanism and Applications Science (New York, N.Y.). Jun, 2013 | Pubmed ID: 23744940 A Functional CFTR Assay Using Primary Cystic Fibrosis Intestinal Organoids Nature Medicine. Jul, 2013 | Pubmed ID: 23727931 Lgr Proteins in Epithelial Stem Cell Biology Development (Cambridge, England). Jun, 2013 | Pubmed ID: 23715542 DNA Methylation Dynamics During Intestinal Stem Cell Differentiation Reveals Enhancers Driving Gene Expression in the Villus Genome Biology. 2013 | Pubmed ID: 23714178 Spdef Null Mice Lack Conjunctival Goblet Cells and Provide a Model of Dry Eye The American Journal of Pathology. Jul, 2013 | Pubmed ID: 23665202 Regulation of Stem Cell Therapies Under Attack in Europe: for Whom the Bell Tolls The EMBO Journal. May, 2013 | Pubmed ID: 23644381 A Positive Feedback Loop Involving Gcm1 and Fzd5 Directs Chorionic Branching Morphogenesis in the Placenta PLoS Biology. 2013 | Pubmed ID: 23610556 Conversion of Mature Human β-cells into Glucagon-producing α-cells Diabetes. Jul, 2013 | Pubmed ID: 23569174 ER Stress Causes Rapid Loss of Intestinal Epithelial Stemness Through Activation of the Unfolded Protein Response Cell Reports. Apr, 2013 | Pubmed ID: 23545496 Live Imaging of Astrocyte Responses to Acute Injury Reveals Selective Juxtavascular Proliferation Nature Neuroscience. May, 2013 | Pubmed ID: 23542688 SnapShot: the Intestinal Crypt Cell. Feb, 2013 | Pubmed ID: 23452862 Stem Cells: A Unifying Theory for the Crypt Nature. Mar, 2013 | Pubmed ID: 23446347 Paneth Cells: Maestros of the Small Intestinal Crypts Annual Review of Physiology. 2013 | Pubmed ID: 23398152 Intestinal Regeneration: YAP-tumor Suppressor and Oncoprotein? Current Biology : CB. Feb, 2013 | Pubmed ID: 23391384 In Vitro Expansion of Single Lgr5+ Liver Stem Cells Induced by Wnt-driven Regeneration Nature. Feb, 2013 | Pubmed ID: 23354049 Immunosurveillance Against Tetraploidization-induced Colon Tumorigenesis Cell Cycle (Georgetown, Tex.). Feb, 2013 | Pubmed ID: 23324343 Intestinal Tumorigenesis Initiated by Dedifferentiation and Acquisition of Stem-cell-like Properties Cell. Jan, 2013 | Pubmed ID: 23273993 Identification of a Clonally Expanding Haematopoietic Compartment in Bone Marrow The EMBO Journal. Jan, 2013 | Pubmed ID: 23188081 Primary Mouse Small Intestinal Epithelial Cell Cultures Methods in Molecular Biology (Clifton, N.J.). 2013 | Pubmed ID: 23097115 Diabetes Risk Gene and Wnt Effector Tcf7l2/TCF4 Controls Hepatic Response to Perinatal and Adult Metabolic Demand Cell. Dec, 2012 | Pubmed ID: 23260145 The Nuclear Effector of Wnt-signaling, Tcf1, Functions As a T-cell-specific Tumor Suppressor for Development of Lymphomas PLoS Biology. 2012 | Pubmed ID: 23185135 Tales of the Unexpected: Tcf1 Functions As a Tumor Suppressor for Leukemias Immunity. Nov, 2012 | Pubmed ID: 23159221 The Paneth Cell, Caloric Restriction, and Intestinal Integrity The New England Journal of Medicine. Oct, 2012 | Pubmed ID: 23075184 Identifying the Stem Cell of the Intestinal Crypt: Strategies and Pitfalls Cell Stem Cell. Oct, 2012 | Pubmed ID: 23040474 Dll1+ Secretory Progenitor Cells Revert to Stem Cells Upon Crypt Damage Nature Cell Biology. Oct, 2012 | Pubmed ID: 23000963 Lgr5(+ve) Stem/progenitor Cells Contribute to Nephron Formation During Kidney Development Cell Reports. Sep, 2012 | Pubmed ID: 22999937 Monoclonal Antibodies Against Lgr5 Identify Human Colorectal Cancer Stem Cells Stem Cells (Dayton, Ohio). Nov, 2012 | Pubmed ID: 22969042 Modulating WNT Receptor Turnover for Tissue Repair Nature Biotechnology. Sep, 2012 | Pubmed ID: 22965053 Developmental Stage-specific Contribution of LGR5(+) Cells to Basal and Luminal Epithelial Lineages in the Postnatal Mammary Gland The Journal of Pathology. Nov, 2012 | Pubmed ID: 22926799 Cell Biology. The Unusual Case of Porcupine Science (New York, N.Y.). Aug, 2012 | Pubmed ID: 22923569 Redundant Sources of Wnt Regulate Intestinal Stem Cells and Promote Formation of Paneth Cells Gastroenterology. Dec, 2012 | Pubmed ID: 22922422 Tumour Suppressor RNF43 is a Stem-cell E3 Ligase That Induces Endocytosis of Wnt Receptors Nature. Aug, 2012 | Pubmed ID: 22895187 Chronic Epithelial NF-κB Activation Accelerates APC Loss and Intestinal Tumor Initiation Through INOS Up-regulation Proceedings of the National Academy of Sciences of the United States of America. Aug, 2012 | Pubmed ID: 22893683 Lineage Tracing Reveals Lgr5+ Stem Cell Activity in Mouse Intestinal Adenomas Science (New York, N.Y.). Aug, 2012 | Pubmed ID: 22855427 Crypt Base Columnar Stem Cells in Small Intestines of Mice Are Radioresistant Gastroenterology. Nov, 2012 | Pubmed ID: 22841781 ACE2 Links Amino Acid Malnutrition to Microbial Ecology and Intestinal Inflammation Nature. Jul, 2012 | Pubmed ID: 22837003 Rap2A Links Intestinal Cell Polarity to Brush Border Formation Nature Cell Biology. Aug, 2012 | Pubmed ID: 22797597 Peyer's Patch M Cells Derived from Lgr5(+) Stem Cells Require SpiB and Are Induced by RankL in Cultured "miniguts" Molecular and Cellular Biology. Sep, 2012 | Pubmed ID: 22778137 The Lgr5 Intestinal Stem Cell Signature: Robust Expression of Proposed Quiescent '+4' Cell Markers The EMBO Journal. Jul, 2012 | Pubmed ID: 22692129 Wnt Signaling Through Inhibition of β-catenin Degradation in an Intact Axin1 Complex Cell. Jun, 2012 | Pubmed ID: 22682247 Wnt/β-catenin Signaling and Disease Cell. Jun, 2012 | Pubmed ID: 22682243 On the Biomechanics of Stem Cell Niche Formation in the Gut--modelling Growing Organoids The FEBS Journal. Sep, 2012 | Pubmed ID: 22632461 Adult Mammalian Stem Cells: the Role of Wnt, Lgr5 and R-spondins The EMBO Journal. Jun, 2012 | Pubmed ID: 22617424 In Vitro Expansion and Transplantation of Intestinal Crypt Stem Cells Gastroenterology. Jul, 2012 | Pubmed ID: 22613623 Wnt/β-catenin and MAPK Signaling: Allies and Enemies in Different Battlefields Science Signaling. Apr, 2012 | Pubmed ID: 22494969 Wnt Signaling, Stem Cells, and Cancer of the Gastrointestinal Tract Cold Spring Harbor Perspectives in Biology. Apr, 2012 | Pubmed ID: 22474007 The R-spondin Protein Family Genome Biology. 2012 | Pubmed ID: 22439850 Functional Engraftment of Colon Epithelium Expanded in Vitro from a Single Adult Lgr5⁺ Stem Cell Nature Medicine. Apr, 2012 | Pubmed ID: 22406745 What Does the Concept of the Stem Cell Niche Really Mean Today? BMC Biology. 2012 | Pubmed ID: 22405133 A Critical Role for the Wnt Effector Tcf4 in Adult Intestinal Homeostatic Self-renewal Molecular and Cellular Biology. May, 2012 | Pubmed ID: 22393260 Lrig1 Controls Intestinal Stem-cell Homeostasis by Negative Regulation of ErbB Signalling Nature Cell Biology. Apr, 2012 | Pubmed ID: 22388892 Optimality in the Development of Intestinal Crypts Cell. Feb, 2012 | Pubmed ID: 22304925 Method for Estimating the Single Molecular Affinity Analytical Biochemistry. Feb, 2012 | Pubmed ID: 22209736 Cdx2 Determines the Fate of Postnatal Intestinal Endoderm Development (Cambridge, England). Feb, 2012 | Pubmed ID: 22190642 Controlled Gene Expression in Primary Lgr5 Organoid Cultures Nature Methods. Jan, 2012 | Pubmed ID: 22138822 Single-molecule Transcript Counting of Stem-cell Markers in the Mouse Intestine Nature Cell Biology. Jan, 2012 | Pubmed ID: 22119784 Integrated Genome-wide Analysis of Transcription Factor Occupancy, RNA Polymerase II Binding and Steady-state RNA Levels Identify Differentially Regulated Functional Gene Classes Nucleic Acids Research. Jan, 2012 | Pubmed ID: 21914722 Neural Stem Cells for Diabetes Cell-based Therapy EMBO Molecular Medicine. Dec, 2011 | Pubmed ID: 22238783 Single-cell Dissection of Transcriptional Heterogeneity in Human Colon Tumors Nature Biotechnology. Dec, 2011 | Pubmed ID: 22081019 Isolation and in Vitro Expansion of Human Colonic Stem Cells Nature Medicine. Oct, 2011 | Pubmed ID: 21892181 Long-term Expansion of Epithelial Organoids from Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium Gastroenterology. Nov, 2011 | Pubmed ID: 21889923 The BMP Antagonist Follistatin-like 1 is Required for Skeletal and Lung Organogenesis PloS One. 2011 | Pubmed ID: 21826198 Slide Preparation for Single-cell-resolution Imaging of Fluorescent Proteins in Their Three-dimensional Near-native Environment Nature Protocols. Aug, 2011 | Pubmed ID: 21799490 Stem Cell Self-renewal in Intestinal Crypt Experimental Cell Research. Nov, 2011 | Pubmed ID: 21787769 Lgr5 Homologues Associate with Wnt Receptors and Mediate R-spondin Signalling Nature. Aug, 2011 | Pubmed ID: 21727895 Retinoic Acid-induced Pancreatic Stellate Cell Quiescence Reduces Paracrine Wnt-β-catenin Signaling to Slow Tumor Progression Gastroenterology. Oct, 2011 | Pubmed ID: 21704588 Highly Sensitive Proteome Analysis of FACS-sorted Adult Colon Stem Cells Journal of Proteome Research. Aug, 2011 | Pubmed ID: 21696214 Actomyosin-mediated Cellular Tension Drives Increased Tissue Stiffness and β-catenin Activation to Induce Epidermal Hyperplasia and Tumor Growth Cancer Cell. Jun, 2011 | Pubmed ID: 21665151 Strategies for Homeostatic Stem Cell Self-renewal in Adult Tissues Cell. Jun, 2011 | Pubmed ID: 21663791 Differentiated Human Colorectal Cancer Cells Protect Tumor-initiating Cells from Irinotecan Gastroenterology. Jul, 2011 | Pubmed ID: 21459094 The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem Cells and Predicts Disease Relapse Cell Stem Cell. May, 2011 | Pubmed ID: 21419747 The Cancer Stem Cell: Premises, Promises and Challenges Nature Medicine. Mar, 2011 | Pubmed ID: 21386835 Distinct ATOH1 and Neurog3 Requirements Define Tuft Cells As a New Secretory Cell Type in the Intestinal Epithelium The Journal of Cell Biology. Mar, 2011 | Pubmed ID: 21383077 The Serine-threonine Kinase LKB1 is Essential for Survival Under Energetic Stress in Zebrafish Proceedings of the National Academy of Sciences of the United States of America. Mar, 2011 | Pubmed ID: 21368212 Lgr5 Intestinal Stem Cells Have High Telomerase Activity and Randomly Segregate Their Chromosomes The EMBO Journal. Mar, 2011 | Pubmed ID: 21297579 A Comprehensive Model of the Spatio-temporal Stem Cell and Tissue Organisation in the Intestinal Crypt PLoS Computational Biology. 2011 | Pubmed ID: 21253562 Tracking Adult Stem Cells EMBO Reports. Feb, 2011 | Pubmed ID: 21252944 Sox9 Marks Adult Organ Progenitors Nature Genetics. Jan, 2011 | Pubmed ID: 21217637 Paneth Cells Constitute the Niche for Lgr5 Stem Cells in Intestinal Crypts Nature. Jan, 2011 | Pubmed ID: 21113151 Sumoylation by Ubc9 Regulates the Stem Cell Compartment and Structure and Function of the Intestinal Epithelium in Mice Gastroenterology. Jan, 2011 | Pubmed ID: 20951138 Efficient Double Fragmentation ChIP-seq Provides Nucleotide Resolution Protein-DNA Binding Profiles PloS One. 2010 | Pubmed ID: 21152096 Tissue-resident Adult Stem Cell Populations of Rapidly Self-renewing Organs Cell Stem Cell. Dec, 2010 | Pubmed ID: 21112561 The Leukemia-associated Mllt10/Af10-Dot1l Are Tcf4/β-catenin Coactivators Essential for Intestinal Homeostasis PLoS Biology. 2010 | Pubmed ID: 21103407 Chemoprevention by Nonsteroidal Anti-inflammatory Drugs Eliminates Oncogenic Intestinal Stem Cells Via SMAC-dependent Apoptosis Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21041628 The Cytomegalovirus-encoded Chemokine Receptor US28 Promotes Intestinal Neoplasia in Transgenic Mice The Journal of Clinical Investigation. Nov, 2010 | Pubmed ID: 20978345 P21 Loss Blocks Senescence Following Apc Loss and Provokes Tumourigenesis in the Renal but Not the Intestinal Epithelium EMBO Molecular Medicine. Nov, 2010 | Pubmed ID: 20976827 Intestinal Stem Cells Lacking the Math1 Tumour Suppressor Are Refractory to Notch Inhibitors Nature Communications. 2010 | Pubmed ID: 20975679 Intestinal Crypt Homeostasis Results from Neutral Competition Between Symmetrically Dividing Lgr5 Stem Cells Cell. Oct, 2010 | Pubmed ID: 20887898 Cyclin D2-cyclin-dependent Kinase 4/6 is Required for Efficient Proliferation and Tumorigenesis Following Apc Loss Cancer Research. Oct, 2010 | Pubmed ID: 20736363 Focal Adhesion Kinase is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling Developmental Cell. Aug, 2010 | Pubmed ID: 20708588 TCF4 and CDX2, Major Transcription Factors for Intestinal Function, Converge on the Same Cis-regulatory Regions Proceedings of the National Academy of Sciences of the United States of America. Aug, 2010 | Pubmed ID: 20696899 Stem Cells and Cancer of the Stomach and Intestine Molecular Oncology. Oct, 2010 | Pubmed ID: 20598659 Wnts As Self-renewal Factors: Mammary Stem Cells and Beyond Cell Stem Cell. Jun, 2010 | Pubmed ID: 20569681 Indian Hedgehog Regulates Intestinal Stem Cell Fate Through Epithelial-mesenchymal Interactions During Development Gastroenterology. Sep, 2010 | Pubmed ID: 20542037 Lineage Tracing in the Intestinal Epithelium Current Protocols in Stem Cell Biology. May, 2010 | Pubmed ID: 20443207 Leucine-rich Repeat-containing G-protein-coupled Receptors As Markers of Adult Stem Cells Gastroenterology. May, 2010 | Pubmed ID: 20417836 Active Wnt Signaling in Response to Cardiac Injury Basic Research in Cardiology. Sep, 2010 | Pubmed ID: 20373104 Loss of the Tumor Suppressor CYLD Enhances Wnt/beta-catenin Signaling Through K63-linked Ubiquitination of Dvl Molecular Cell. Mar, 2010 | Pubmed ID: 20227366 Lgr6 Marks Stem Cells in the Hair Follicle That Generate All Cell Lineages of the Skin Science (New York, N.Y.). Mar, 2010 | Pubmed ID: 20223988 Spindle Orientation Bias in Gut Epithelial Stem Cell Compartments is Lost in Precancerous Tissue Cell Stem Cell. Feb, 2010 | Pubmed ID: 20144789 MAP3K1 Functionally Interacts with Axin1 in the Canonical Wnt Signalling Pathway Biological Chemistry. Feb-Mar, 2010 | Pubmed ID: 20128690 Coexistence of Quiescent and Active Adult Stem Cells in Mammals Science (New York, N.Y.). Jan, 2010 | Pubmed ID: 20110496 Lgr5(+ve) Stem Cells Drive Self-renewal in the Stomach and Build Long-lived Gastric Units in Vitro Cell Stem Cell. Jan, 2010 | Pubmed ID: 20085740 Conversion of Metaplastic Barrett's Epithelium into Post-mitotic Goblet Cells by Gamma-secretase Inhibition Disease Models & Mechanisms. Jan-Feb, 2010 | Pubmed ID: 20075383 In Situ Hybridization to Identify Gut Stem Cells Current Protocols in Stem Cell Biology. Jan, 2010 | Pubmed ID: 20049690 Distinct Gene Mutation Profiles Among Luminal-type and Basal-type Breast Cancer Cell Lines Breast Cancer Research and Treatment. May, 2010 | Pubmed ID: 19593635 Searching for Adult Stem Cells in the Intestine EMBO Molecular Medicine. Aug, 2009 | Pubmed ID: 20049728 Fishing for Intestinal Cancer Models: Unraveling Gastrointestinal Homeostasis and Tumorigenesis in Zebrafish Zebrafish. Dec, 2009 | Pubmed ID: 19929219 Phosphatidylinositol 3-kinase Signaling Does Not Activate the Wnt Cascade The Journal of Biological Chemistry. Dec, 2009 | Pubmed ID: 19850932 Eyeing Up New Wnt Pathway Players Cell. Oct, 2009 | Pubmed ID: 19837026 The Kinase TNIK is an Essential Activator of Wnt Target Genes The EMBO Journal. Nov, 2009 | Pubmed ID: 19816403 SPDEF is Required for Mouse Pulmonary Goblet Cell Differentiation and Regulates a Network of Genes Associated with Mucus Production The Journal of Clinical Investigation. Oct, 2009 | Pubmed ID: 19759516 A Genome-wide Screen for Spatially Restricted Expression Patterns Identifies Transcription Factors That Regulate Glial Development The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2009 | Pubmed ID: 19741146 P53 Deletion Impairs Clearance of Chromosomal-instable Stem Cells in Aging Telomere-dysfunctional Mice Nature Genetics. Oct, 2009 | Pubmed ID: 19718028 LKB1 and AMPK Family Signaling: the Intimate Link Between Cell Polarity and Energy Metabolism Physiological Reviews. Jul, 2009 | Pubmed ID: 19584313 The Ets-domain Transcription Factor Spdef Promotes Maturation of Goblet and Paneth Cells in the Intestinal Epithelium Gastroenterology. Oct, 2009 | Pubmed ID: 19549527 HDAC1 and HDAC2 Regulate Oligodendrocyte Differentiation by Disrupting the Beta-catenin-TCF Interaction Nature Neuroscience. Jul, 2009 | Pubmed ID: 19503085 OLFM4 is a Robust Marker for Stem Cells in Human Intestine and Marks a Subset of Colorectal Cancer Cells Gastroenterology. Jul, 2009 | Pubmed ID: 19450592 Mst4 and Ezrin Induce Brush Borders Downstream of the Lkb1/Strad/Mo25 Polarization Complex Developmental Cell. Apr, 2009 | Pubmed ID: 19386264 Single Lgr5 Stem Cells Build Crypt-villus Structures in Vitro Without a Mesenchymal Niche Nature. May, 2009 | Pubmed ID: 19329995 Prominin-1/CD133 Marks Stem Cells and Early Progenitors in Mouse Small Intestine Gastroenterology. Jun, 2009 | Pubmed ID: 19324043 Transcription Factor Achaete Scute-like 2 Controls Intestinal Stem Cell Fate Cell. Mar, 2009 | Pubmed ID: 19269367 Wnt Signaling, Lgr5, and Stem Cells in the Intestine and Skin The American Journal of Pathology. Mar, 2009 | Pubmed ID: 19197002 Identification of Primary MAFB Target Genes in Multiple Myeloma Experimental Hematology. Jan, 2009 | Pubmed ID: 19013005 Stem Cells, Self-renewal, and Differentiation in the Intestinal Epithelium Annual Review of Physiology. 2009 | Pubmed ID: 18808327 The Intestinal Stem Cell Genes & Development. Jul, 2008 | Pubmed ID: 18628392 Transcription Factor Target Practice Cell. Jan, 2006 | Pubmed ID: 16413477 Down-regulation of Rap1 Activity is Involved in EphrinB1-induced Cell Contraction The Biochemical Journal. Jul, 2005 | Pubmed ID: 15725075 Differential Contribution of the Immunoreceptor Tyrosine-based Inhibitory Motifs of Human Leukocyte-associated Ig-like Receptor-1 to Inhibitory Function and Phosphatase Recruitment International Immunology. Nov, 2003 | Pubmed ID: 14565933 Identification of Two Novel Regulated Serines in the N Terminus of Beta-catenin Experimental Cell Research. Jun, 2002 | Pubmed ID: 12027456 The Axin-like Protein PRY-1 is a Negative Regulator of a Canonical Wnt Pathway in C. Elegans Genes & Development. May, 2002 | Pubmed ID: 12023307 Wnt Signaling Controls the Phosphorylation Status of Beta-catenin The Journal of Biological Chemistry. May, 2002 | Pubmed ID: 11834740 Wnt Signals Are Transmitted Through N-terminally Dephosphorylated Beta-catenin EMBO Reports. Jan, 2002 | Pubmed ID: 11751573 The Chromatin Remodelling Factor Brg-1 Interacts with Beta-catenin to Promote Target Gene Activation The EMBO Journal. Sep, 2001 | Pubmed ID: 11532957 All Tcf HMG Box Transcription Factors Interact with Groucho-related Co-repressors Nucleic Acids Research. Apr, 2001 | Pubmed ID: 11266540 Modeling Breast Cancer Using CRISPR-Cas9-Mediated Engineering of Human Breast Organoids Journal of the National Cancer Institute. | Pubmed ID: 31589320 Создание, поддержание, дифференциация, генетические манипуляции и трансплантация органоидов слезных желез мыши и человека Marie Bannier-Hélaouët1,2, Maarten H. Geurts1,2, Jeroen Korving1, Harry Begthel1, Hans Clevers1,2 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, 2Oncode Institute, Hubrecht Institute JoVE 65040 Biología Medium-Throughput Drug- and Radiotherapy Screening Assay using Patient-Derived Organoids JoVE 62495 Investigación sobre el cáncer Форсколин-индуцированной Отек в кишечном органоидов: Sylvia F. Boj1, Annelotte M. Vonk2, Marvin Statia1, Jinyi Su1, Johanna F. Dekkers3, Robert R. G. Vries1, Jeffrey M. Beekman2, Hans Clevers1,4 1Foundation Hubrecht Organoid Technology, 2Department of Pediatric Pulmonology, Regenerative Medicine Centre Utrecht, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3Department of Stem Cells and Cancer, Walter and Eliza Hall Institute of Medical Research, 4Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht Medicina Органоиды как модель для инфекционных болезней: Культура человека и мыши желудка органоидов и Микроинъекция Helicobacter Pylori Sina Bartfeld1, Hans Clevers1 1Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht Inmunología e infección
Создание, поддержание, дифференциация, генетические манипуляции и трансплантация органоидов слезных желез мыши и человека Marie Bannier-Hélaouët1,2, Maarten H. Geurts1,2, Jeroen Korving1, Harry Begthel1, Hans Clevers1,2 1Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences (KNAW), University Medical Center Utrecht, 2Oncode Institute, Hubrecht Institute JoVE 65040 Biología
Medium-Throughput Drug- and Radiotherapy Screening Assay using Patient-Derived Organoids JoVE 62495 Investigación sobre el cáncer
Форсколин-индуцированной Отек в кишечном органоидов: Sylvia F. Boj1, Annelotte M. Vonk2, Marvin Statia1, Jinyi Su1, Johanna F. Dekkers3, Robert R. G. Vries1, Jeffrey M. Beekman2, Hans Clevers1,4 1Foundation Hubrecht Organoid Technology, 2Department of Pediatric Pulmonology, Regenerative Medicine Centre Utrecht, Wilhelmina Children's Hospital, University Medical Centre Utrecht, 3Department of Stem Cells and Cancer, Walter and Eliza Hall Institute of Medical Research, 4Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht Medicina
Органоиды как модель для инфекционных болезней: Культура человека и мыши желудка органоидов и Микроинъекция Helicobacter Pylori Sina Bartfeld1, Hans Clevers1 1Hubrecht Institute for Developmental Biology and Stem Cell Research, University Medical Centre Utrecht Inmunología e infección
