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Investigating HFpEF Pathophysiology in a Hyperlipidemia-Induced Mouse Model

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Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

JoVE Journal
Medizin

This content is Free Access.

JoVE Journal Medizin

A Murine Model of Hyperlipidemia-Induced Heart Failure with Preserved Ejection Fraction

Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Investigating HFpEF Pathophysiology in a Hyperlipidemia-Induced Mouse Model

DOI:

10.3791/66442-v

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01:59 min

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March 29, 2024

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Monique Williams², Ali Kamiar³, Jose Manuel Condor Capcha², Monica Anne Rasmussen, Qusai Alitter, Rosemeire Kanashiro Takeuchi³, Lauro Mitsuru Takeuchi, Joshua M. Hare², Lina A. Shehadeh²

¹Department of Medicine, Division of Cardiology,University of Miami Leonard M. Miller School of Medicine, ²Interdisciplinary Stem Cell Institute,University of Miami Leonard M. Miller School of Medicine, ³Department of Molecular and Cellular Pharmacology,University of Miami Leonard M. Miller School of Medicine, ⁴Department of Medical Education,University of Miami Leonard M. Miller School of Medicine

Tags

Hyperlipidemia Heart Failure With Preserved Ejection Fraction (HFpEF)Murine Model Poloxamer-407 (P-407)Adeno-associated Virus 9-cardiac Troponin T-low-density Lipoprotein Receptor (AAV9-cTnT-LDLR)Diastolic Dysfunction Cardiac Ischemia Metabolic Syndrome Lipotoxicity

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Author Spotlight: Exploring the Relationship Between Lipotoxicity and HFpEF

Inducing Hyperlipidemia to Characterize Diastolic Dysfunction in HFpEF Mice

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