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Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays…
JoVE Journal
Neuroscience
Neuroscience
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Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
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Focused Ultrasound Neuromodulation of Human In Vitro Neural Cultures in Multi-Well Microelectrode Arrays
May 3rd, 2024
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Ruixing Liang1,2, Griffin Mess2,3, Joshua Punnoose2,3, Kelley M. Kempski Leadingham2,3, Constantin Smit2,3, Nitish Thakor1,4, Christa W. Habela3, Betty Tyler3, Yousef Salimpour3, Amir Manbachi1,2,3,4,5,6
1Electrical and Computer Engineering, Johns Hopkins University, 2HEPIUS Innovation Laboratory, Johns Hopkins University School of Medicine, 3Neurosurgery, Johns Hopkins University School of Medicine, 4Biomedical Engineering, Johns Hopkins University School of Medicine, 5Mechanical Engineering, Johns Hopkins University, 6Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine
Kapitel
Summary
Here, we present a protocol for using a high-throughput system that enables the monitoring and quantification of the neuromodulatory effects of focused ultrasound on human-induced pluripotent stem cell (HiPSC) neurons.
