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Journal / Neuroscience / Imaging CD19+ B Cells in an Experimental…
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Neuroscience

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JoVE Journal Neuroscience
Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography
 

Imaging CD19+ B Cells in an Experimental Autoimmune Encephalomyelitis Mouse Model using Positron Emission Tomography

Article DOI: 10.3791/64133-v • 09:41 min • January 20th, 2023
January 20th, 2023 •
*1, *1, 1, 1, 1, 1, 1,2
1Department of Radiology, Stanford University, 2Department of Neurology and Neurological Sciences, Stanford University
* These authors contributed equally

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Summary
Automatic Translation

This paper details methodology for radiolabeling a human-specific anti-CD19 monoclonal antibody and how to use it to quantify B cells in the central nervous system and peripheral tissues of a mouse model of multiple sclerosis using in vivo PET imaging, ex vivo gamma counting, and autoradiography approaches.

Tags

Imaging CD19+ B Cells Experimental Autoimmune Encephalomyelitis Mouse Model Positron Emission Tomography Multiple Sclerosis Demyelinating Central Nervous System Disease B Lymphocytes MS Pathology Anti-B Cell Therapies PET Imaging In Vivo Spatiotemporal Distribution B Cell Load PET Tracer Human CD19+ B Cells B Cell-driven Mouse Model Of MS Myelin Oligodendrocyte Glycoprotein 1-125 Brain And Spinal Cord Imaging In Vivo PET Imaging Ex Vivo Gamma Counting Disease-relevant Organs Autoradiography
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