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Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine
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JoVE Journal Chemie
Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

Preparation of Enantiopure Non-Activated Aziridines and Synthesis of Biemamide B, D, and epiallo-Isomuscarine

DOI:
10.3791/63705-v

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11:04 min

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June 13, 2022

•

,
1Department of Chemistry,Hankuk University of Foreign Studies

Kapitel

  • 00:04Introduction
  • 01:31Synthesis of the Diastereomeric Mixture of Chiral Aziridine (-)-Mentholyl Ester Derivative
  • 06:38Regio and Stereoselective Aziridine Ring-Opening by Azide Nucleophile for the Total Synthesis of Biemamide B and Biemamide D
  • 08:33Results: Synthesis of Aziridine-2-Carboxylates, Biemamide, and Epiallo-Isomuscarine
  • 10:16Conclusion

Summary

Automatische Übersetzung

Automatische Übersetzung

In this study, we prepare both enantiomers of aziridine-2-carboxylate, which are used in the asymmetric synthesis of alkaloids, including biemamide B and D, and (-)-epiallo-isomuscarine.

Tags

Enantiopure AziridinesBiemamide BBiemamide DEpiallo-isomuscarineAsymmetric SynthesisCrystallizationLarge-scale PreparationNon-activated AziridinesAziridine-2 Carboxylate

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