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Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications
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Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications

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08:46 min

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April 21, 2022

DOI:

10.3791/63587-v

DOI:
10.3791/63587-v

•

08:46 min
April 21, 2022

•

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1Environmental and Occupational Health Sciences Institute,Rutgers University, 2Department of Biochemistry and Microbiology,Rutgers University, 3Centro de Química Estrutural and Departamento de Química e Bioquímica, Faculdade de Ciências,Universidade de Lisboa

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The increased rate of pharmaco- and toxicokinetic analyses of metals and metal-based compounds in zebrafish can be advantageous for environmental and clinical translation studies. The limitation of unknown waterborne exposure uptake was overcome by conducting trace metal analysis on digested zebrafish tissue using inductively coupled plasma mass spectrometry.

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ZebrafishDose UptakePlatinumRutheniumInductively Coupled Plasma Mass Spectrometry (ICPMS)Matrix-matched CalibrationIsobaric InterferenceMetal ExposurePharmacologyEnvironmental Science

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Karas, B. F., Doherty, C. L., Terez, K. R., Côrte-Real, L., Cooper, K. R., Buckley, B. T. Dose Uptake of Platinum- and Ruthenium-based Compound Exposure in Zebrafish by Inductively Coupled Plasma Mass Spectrometry with Broader Applications. J. Vis. Exp. (182), e63587, doi:10.3791/63587 (2022).

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