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Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome
JoVE Journal
Immunologie und Infektion
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JoVE Journal Immunologie und Infektion
Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

Mouse Model of Oleic Acid-Induced Acute Respiratory Distress Syndrome

1,775 Views

04:45 min

June 02, 2022

DOI:

04:45 min
June 02, 2022

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Summary

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The present protocol describes a lung injury model in mice using oleic acid to mimic acute respiratory distress syndrome (ARDS). This model increases the inflammatory mediators on edema and decreases lung compliance. Oleic acid is used in the salt form (oleate) since this physiological form avoids the risk of embolism.

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