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测量成年小鼠急性纹状体切片中的耗氧率
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JoVE Journal Neurowissenschaften
Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice
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测量成年小鼠急性纹状体切片中的耗氧率

2,854 Views

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07:41 min

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June 08, 2022

DOI:

10.3791/63379-v

DOI:
10.3791/63379-v

•

07:41 min
June 08, 2022

•

38 Views
, , , , , , , ,
1Department of Neuroscience,Thomas Jefferson University, 2School of Biomedical Engineering,Drexel University, 3Department of Pathology, MitoCare Center,Thomas Jefferson University, 4School of Life Sciences,Peking University

Summary

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耗氧率（OCR）是线粒体功能的常见代理，可用于研究不同的疾病模型。我们开发了一种使用Seahorse XF分析仪的新方法，直接测量成年小鼠急性纹状体切片中的OCR，该方法比其他方法更具生理相关性。

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Cite this Article

Zhi, L., Zhao, J., Jaffe, D., Chen, Y., Wang, N., Qin, Q., Seifert, E. L., Li, C., Zhang, H. Measurement of Oxygen Consumption Rate in Acute Striatal Slices from Adult Mice. J. Vis. Exp. (184), e63379, doi:10.3791/63379 (2022).

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