This paper describes a handling technique in mice, the 3D-handling technique, which facilitates routine handling by reducing anxiety-like behaviors and presents details on two existing related techniques (tunnel and tail handling).
Marcotte, M., Bernardo, A., Linga, N., Pérez-Romero, C. A., Guillou, J., Sibille, E., Prevot, T. D. Handling Techniques to Reduce Stress in Mice. J. Vis. Exp. (175), e62593, doi:10.3791/62593 (2021).