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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
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Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound
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June 03, 2021
DOI:
1Department of Neurosurgery,University Medical Center of the Johannes Gutenberg-University of Mainz, 2Center for Cardiology – Cardiology I,University Medical Center of the Johannes Gutenberg-University of Mainz, 3Center for Thrombosis and Hemostasis (CTH),University Medical Center of the Johannes Gutenberg-University of Mainz, 4German Center for Cardiovascular Research (DZHK) – Partner site Rhine-Main, 5Department of Anesthesiology,University Medical Center of the Johannes Gutenberg-University of Mainz
Summary
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The aim of this manuscript is to present a sonography-based method that allows in vivo imaging of blood flow in cerebral arteries in mice. We demonstrate its application to determine changes in blood flow velocities associated with vasospasm in murine models of subarachnoid hemorrhage (SAH).
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Neulen, A., Molitor, M., Kosterhon, M., Pantel, T., Karbach, S. H., Wenzel, P., Gaul, T., Ringel, F., Thal, S. C. Analysis of Cerebral Vasospasm in a Murine Model of Subarachnoid Hemorrhage with High Frequency Transcranial Duplex Ultrasound. J. Vis. Exp. (172), e62186, doi:10.3791/62186 (2021).
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