The overall goal of the current study is to present the techniques of induction of myocardial infarction (MI) and post-myocardial infarction heart failure (post-MI HF) in closed-chest, adult Göttingen minipigs and the characterization of post-MI HF model in Göttingen minipigs as compared to Landrace pigs.
Brenner, G. B., Giricz, Z., Garamvölgyi, R., Makkos, A., Onódi, Z., Sayour, N. V., Gergely, T. G., Baranyai, T., Petneházy, Ö., Kőrösi, D., Szabó, G. P., Vago, H., Dohy, Z., Czimbalmos, C., Merkely, B., Boldin-Adamsky, S., Feinstein, E., Horváth, I. G., Ferdinandy, P. Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs. J. Vis. Exp. (170), e61901, doi:10.3791/61901 (2021).