A host-guest complex of cucurbit[7]uril and uric acid was formed in an aqueous solution before adding a small amount into Au NP solution for quantitative surface-enhanced Raman spectroscopy (SERS) sensing using a modular spectrometer.
Chio, W. K., Davison, G., Jones, T., Liu, J., Parkin, I. P., Lee, T. Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril. J. Vis. Exp. (164), e61682, doi:10.3791/61682 (2020).