Electrowetting-based digital microfluidic is a technique that utilizes a voltage-driven change in the apparent contact angle of a microliter-volume droplet to facilitate its manipulation. Combining this with functionalized magnetic beads enables the integration of multiple laboratory unit operations for sample preparation and identification of pathogens using Enzyme-linked Immunosorbent Assay (ELISA).
Dimov, N., McDonnell, M. B., Munro, I., McCluskey, D. K., Johnston, I. D., Tan, C. K. L., Coudron, L. Electrowetting-based Digital Microfluidics Platform for Automated Enzyme-linked Immunosorbent Assay. J. Vis. Exp. (156), e60489, doi:10.3791/60489 (2020).