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Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
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Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin
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10:15 min
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November 01, 2019
DOI:
1Field Neurosciences Institute,Ascension St. Mary’s Hospital, 2Field Neurosciences Institute Laboratory for Restorative Neurology,Central Michigan University, 3Program in Neuroscience,Central Michigan University, 4Department of Psychology,Central Michigan University, 5Department of Health Sciences,Saginaw Valley State University
Summary
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Curcumin is an ideal fluorophore for labeling and imaging of amyloid beta protein plaques in brain tissue due to its preferential binding to amyloid beta protein as well as its structural similarities with other traditional amyloid binding dyes. It can be used to label and image amyloid beta protein plaques more efficiently and inexpensively than traditional methods.
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Cite this Article
Maiti, P., Plemmons, A., Bowers, Z., Weaver, C., Dunbar, G. Labeling and Imaging of Amyloid Plaques in Brain Tissue Using the Natural Polyphenol Curcumin. J. Vis. Exp. (153), e60377, doi:10.3791/60377 (2019).
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